Similar Datasets
Project description:Oryza sativa Japonica Group ALS, Acetolactate synthase (EC4.6.3.8), Acetohydroxy acid synthase, Herbicide resistance (mutated form of rice ALS, OsmALS (W548L/S627I), is expressed in 12 baseline experiment(s);
| Os02g0510200 | ExpressionAtlas
Project description:Oryza sativa Japonica Group ALS, Acetolactate synthase (EC4.6.3.8), Acetohydroxy acid synthase, Herbicide resistance (mutated form of rice ALS, OsmALS (W548L/S627I), is differentially expressed in 17 experiment(s);
| Os02g0510200 | ExpressionAtlas
Project description:Arabidopsis thaliana ALS, Acetolactate synthase, chloroplastic [Source:UniProtKB/Swiss-Prot;Acc:P17597], is differentially expressed in 71 experiment(s);
| AT3G48560 | ExpressionAtlas
Project description:Arabidopsis thaliana ALS, Acetolactate synthase, chloroplastic [Source:UniProtKB/Swiss-Prot;Acc:P17597], is expressed in 16 baseline experiment(s);
| AT3G48560 | ExpressionAtlas
Project description:Numerous genes mutated in amyotrophic lateral sclerosis (ALS) share a role in DNA damage and repair, emphasizing genome disintegration in ALS. DNA instability and repair mechanisms segregate extrachromosomal circular DNAs (ec/eccDNAs) that can modulate gene expression somatically. Here, circulome profiling in a hSOD1G93A genotoxicity model of ALS revealed a 6-fold enrichment of small-size eccDNAs relative to controls. DifCir-based differential analysis identified 189 genes with patterned segregation of differentially produced per gene circles (DPpGCs) from ALS but not from control samples, implicating an inter-sample recurrence rate of at least 89% for the top 6 DPpGCs. Mass spectrometry-based ALS circulome-proteome cross-referencing revealed 31 corresponding differentially expressed proteins (DEPs), with 12 DPpGC-DEP pairs being itemized in ALS risk GWAS databases. DPpGC-DEP hotspots mainly convey neuron-specific functions counteracting ALS detriments. This is unanticipated evidence for non-random, profiled eccDNA accumulation in ALS neurodegeneration, involving putative interactions with their gene products as well as biomarker perspectives.
2023-09-20 | GSE214718 | GEO
Project description:Differentiated motor neurons from hiPSC derived from peripheral nerve fibroblasts of sporadic ALS patients and evaluated the gene expression profile by means microarray-linked to specific analysis tools. Two-condition experiment, ALS patients motor neurons vs. controls. Biological replicates: 3 ALS replicates, 3 control replicates.
2015-04-25 | E-GEOD-68240 | biostudies-arrayexpress