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Synergistic immunochemotherapy exerts efficiently anti-hepatocellular carcinoma effect to induce SAMD4B-APOA2 axis for inhibition of tumor immune evasion [NM-seq]

ABSTRACT: Synergistic immunochemotherapy exerts efficiently anti-hepatocellular carcinoma effect to induce SAMD4B-APOA2 axis for inhibition of tumor immune evasion [NM-seq]

PROVIDER: PRJNA926986 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR23205062.fastq.gz	Fastqsanger.gz
	SRR23205063.fastq.gz	Fastqsanger.gz
	SRR23205064.fastq.gz	Fastqsanger.gz
	SRR23205065.fastq.gz	Fastqsanger.gz
	SRR23205066.fastq.gz	Fastqsanger.gz

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Synergistic immunochemotherapy exerts efficiently anti-hepatocellular carcinoma effect to induce SAMD4B-APOA2 axis for inhibition of tumor immune evasion [NM-seq]

Project description:RNA modifications are a type of post-transcriptional modification and involved in many biological processes of immune cells, thus regulating immune response and participating in immune related diseases. 2'-O-methylation is one of the most common modifications. However, whether 2’-O-methylation is involved in immune evasion via regulating programmed death ligand 1 (PD-L1) is unclear. Here, we were the first to propose a new treatment strategy for patients with advanced hepatocellular carcinoma (HCC), provided evidence that synergistic immunochemotherapy had a better prognosis, and revealing the mechanism of immune regulation through 2'-O-methylation modification mediated by SAMD4B, as a tumor suppressor gene.

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Synergistic immunochemotherapy exerts efficiently anti-hepatocellular carcinoma effect to induce SAMD4B-APOA2 axis for inhibition of tumor immune evasion

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Synergistic immunochemotherapy exerts efficiently anti-hepatocellular carcinoma effect to induce SAMD4B-APOA2 axis for inhibition of tumor immune evasion

Project description:The purpose of this study is to speculate TCC (Thalidomide+carmofur+ Cantharidin), may be a promising treatment strategy for patients with advanced HCC.However, there is few research on this novel clinical combination therapy, especially the mechanism of its anti-hepatocellular effect. Therefore, it is necessary to further explore the specific mechanism of triple drug combination in HCC treatment.Here, we prospectively collected the clinical data of 92 patients with unresectable HCC, observed the effective efficacy of TCC in clinical practice, and confirmed in 6 PDX models in mice.Later on, we collected the resected tumors conducted single cell sequencing (scRNA-seq). We found that SAMD4B, especially its expression level, could affect the immune microenvironment. In order to understand the details of its immune regulation mechanism, such as which immune cells PD1 (i.e. PD-L1 receptor regulated by SAMD4B) comes from, we selected 4 patients from low- and high-SAMD4B groups for scRNA-seq.

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