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Early Transcriptional Responses to Human Paratyphoid Challenge

ABSTRACT: Early Transcriptional Responses to Human Paratyphoid Challenge

PROVIDER: PRJNA929287 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR23268557_1.fastq.gz	Fastqsanger.gz
	SRR23268557_2.fastq.gz	Fastqsanger.gz
	SRR23268558_1.fastq.gz	Fastqsanger.gz
	SRR23268558_2.fastq.gz	Fastqsanger.gz
	SRR23268559_1.fastq.gz	Fastqsanger.gz

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Early Transcriptional Responses to Human Paratyphoid Challenge

Project description:The whole blood transcriptome 12 hours after challenge with S. Paratyphi A. Samples were collected in a study aiming to find the challenge dose giving a 60-75% attack rate, published in Dobinson et al. PMID: 28158395. Participants were challenged with S. Paratyphi A NVGH308 strain suspended in sodium bicarbonate. Enteric fever was diagnosed based on oral temperature or positive blood culture. Participants were treated with antibiotics either following diagnosis or 14 days without diagnosis. Paired baseline samples are available under Series GSE114033.

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