Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Single-cell RNA sequencing of peripheral blood mononuclear cells (PBMCs) from Kimura disease patient treated with dupilumab

ABSTRACT: Single-cell RNA sequencing of peripheral blood mononuclear cells (PBMCs) from Kimura disease patient treated with dupilumab

PROVIDER: PRJNA929969 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR23289852.fastq.gz	Fastqsanger.gz
	SRR23289853.fastq.gz	Fastqsanger.gz
	SRR23289854.fastq.gz	Fastqsanger.gz
	SRR23289855.fastq.gz	Fastqsanger.gz
	SRR23289856.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 8

Similar Datasets

Single-cell RNA sequencing of peripheral blood mononuclear cells (PBMCs) from Kimura disease patient treated with dupilumab

Project description:We performed single-cell RNA sequencing of PBMCs from Kimura disease patient succesfully treated with dupilumab to explore the mechanism of action of dupilumab treatment.

2023-06-01 | GSE224144 | GEO

miR from peripheral blood mononuclear cells' (PBMCs') exosome

Project description:miR from peripheral blood mononuclear cells' (PBMCs') exosome

| PRJNA786954 | ENA

Differenatiation of miRNA expression in PBMCs (peripheral blood mononuclear cells)

Project description:Differenatiation of miRNA expression in PBMCs (peripheral blood mononuclear cells)

| PRJNA550408 | ENA

Goat Peripheral Blood Mononuclear Cells (PBMCs) responses to infection vary with Peste des Petits Ruminants Virus virulence

Project description:Peste des Petits Ruminants (PPR) is a highly infectious disease caused by a virus of the genus Morbillivirus (PPRV), infecting mainly sheep and goat. Susceptibility of host can vary widely with host breed and virus strain. The mechanisms underlying this variability are not well understood. Here, we carried out the first comparative in vitro study on goat peripheral blood mononuclear cells (PBMCs) infected with PPRV strains of different virulence, vaccine strain (N75/1), low- (IC89), and high-virulent strain (MA08). Goat PBMCs were infected by the different strains and stimulated with Concanavalin A (Con A), and proteome changes of these cells were evaluated during the infection. The level of PPRV replication was assessed first by RT-qPCR quantification of viral N mRNA and by labelling the viral N protein inside the cells with specific antibodies and analysed by flow cytometry. The dynamics of PBMC sub-populations were also evaluated by flow cytometry. Our results showed that viral replication is critical for PPRV inhibitory effect on PBMCs proliferation. Highly virulent MA08 strain reached a higher level of replication in ConA-stimulated PBMCs and induced higher mortality compared to other strains. Low-virulent IC89 strain showed the lower replication level and cell proliferative inhibitory capacities. Differences in immune genes expression levels were assessed using RNAseq analysis and protein expression was compared using mass spectrometry. Analysis of these data provided the transcriptional and proteome landscape of PBMCs infected with these strains. The possible association between the transcriptional and proteome landscape and changes in immune cell subpopulations dynamics was explored.

2021-11-03 | PXD024890 | Pride

Signature of circular RNAs in peripheral blood mononuclear cells (PBMCs) from patients with active tuberculosis

Project description:The knowledge of circRNAs in tuberculosis (TB) remains limited. Aim of the present study was to characterize the expression profiles and potential function of circRNAs in human peripheral blood mononuclear cells (PBMCs) from patients with active TB.

2018-12-29 | GSE117563 | GEO

Whole transcriptome analysis of EBV infected peripheral blood mononuclear cells (PBMCs)

Project description:Whole transcriptome analysis of EBV infected peripheral blood mononuclear cells (PBMCs)

| PRJNA988068 | ENA

Microarray analysis of peripheral blood mononuclear cells (PBMCs) from IgA nephropathy patients, membranous nephropathy patients and healthy controls.

Project description:To search for new markers of active lesions that might help better understand the molecular basis of MN and IgAN and aid in their diagnosis, DNA microarray analysis was performed with peripheral blood mononuclear cells (PBMCs)

2016-04-22 | GSE73953 | GEO

Sen2020 - Metabolic alteration in PBMCs associated with type 1 diabetes

Project description:Genome-Scale draft model for Human Peripheral Blood Mononuclear Cells (PBMCs). A GEM for PBMCs was developed by applying the INIT algorithm on Human Metabolic Reconstruction (HMR 2.0) as a template model. GEMs were contextualised/ constrained for different conditions using expression datasets. The gene/transcript expression data obtained from PBMCs of Type 1 Diabetes progressors, non-progressors, and healthy controls were employed to score each reaction of HMR 2.0. For further detail please refer to Electronic Supplementary Information of Sen et.al, Metabolic alterations in immune cells associate with progression to type 1 diabetes, Diabetologia, 15/01/2020, (https://doi.org/10.1007/s00125-020-05107-6).

2020-03-11 | MODEL1905270001 | BioModels

Focused transcription profiling of peripheral blood mononuclear cells from vasculitis patients

Project description:Peripheral blood mononuclear cells (PBMCs) from 13 vasculitis patients expressed varying gene profiles.

2010-11-10 | GSE18247 | GEO

Comparative transcription profiling of peripheral blood mononuclear cells from vasculitis patients

Project description:Peripheral blood mononuclear cells (PBMCs) from 13 vasculitis patients expressed varying gene profiles.

2010-11-10 | GSE16945 | GEO