Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Effects of Klf4 knockdown in GT1-7 cells

ABSTRACT: Effects of Klf4 knockdown in GT1-7 cells

PROVIDER: PRJNA932266 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR23361567_1.fastq.gz	Fastqsanger.gz
	SRR23361567_2.fastq.gz	Fastqsanger.gz
	SRR23361568_1.fastq.gz	Fastqsanger.gz
	SRR23361568_2.fastq.gz	Fastqsanger.gz
	SRR23361569_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 24

Similar Datasets

Effects of Klf4 knockdown in GT1-7 cells

Project description:The goal is to examine the relative abundance of Agrp transcripts and changes to gene expression within GT1-7 cells (immortalized mouse hypothalamic cell line, used as a model of AgRP neurons) treated with Klf4 siRNA, scramble siRNA, or Ca2+ DMEM (vehicle).

2024-06-03 | GSE224716 | GEO

KLF4 knockdown in human keratinocytes

Project description:KLF4 knockdown in human keratinocytes

| PRJNA565412 | ENA

Expression data from GT1-7 cells after treatment with GnRH

Project description:Analysis of GT1-7 cells treated with GnRH. In this dataset, we include the expression data obtained from GT1-7 cells after treatment with GnRH. We confirmed that GT1-7 cells expressed DUSP5 and DUSP6 after GnRH treatment. Results provide insight into the effect of GnRH on MAP kinase pathway.

2018-05-31 | GSE112857 | GEO

Prion infected ScN2a and GT1

Project description:A comparison of prion infected and non-infected samples from neuroblastoma cells (N2a), and a comparison of prion infected and non-infected samples from hypothalmus cells (GT1). 11 dual-color DNA-chip hybridizations of cDNAs were made. Keywords: other

2005-08-24 | GSE1803 | GEO

Parasite gene expression differences between RH-ERP, RH-JSR and GT1 of Toxoplasma gondii.

Project description:Parasite gene expression differences have been reported previously between RH-ERP, RH-JSR and GT1. To independently confirm these gene expression differences, we examined the parasite gene expression profiles of RH-ERP, RH-JSR and GT1 through microarray.

2013-08-20 | GSE44191 | GEO

Prion infected ScN2a and GT1

2010-06-09 | E-GEOD-1803 | biostudies-arrayexpress

KLF4-PFKFB3-driven glycolysis is essential for phenotypic switching of vascular smooth muscle cells

Project description:Vascular smooth muscle cells (VSMCs) within atherosclerotic lesions undergo a phenotypic switching in a KLF4-dependent manner. Glycolysis plays important roles in transdifferentiation of somatic cells, however, it is unclear whether and how KLF4 mediates the link between glycolytic switch and VSMCs phenotypic transitions. Here, we show that KLF4 upregulation accompanies VSMCs phenotypic switching in atherosclerotic lesions. KLF4 enhances the metabolic switch to glycolysis through increasing PFKFB3 expression. Inhibiting glycolysis suppresses KLF4-induced VSMCs phenotypic switching, demonstrating that glycolytic shift is required for VSMCs phenotypic switching. Mechanistically, KLF4 upregulates expression of circCTDP1 and eEF1A2, both of which cooperatively promote PFKFB3 expression. TMAO induces glycolytic shift and VSMCs phenotypic switching by upregulating KLF4. Our study indicates that KLF4 mediates the link between glycolytic switch and VSMCs phenotypic transitions, suggesting that a previously unrecognized KLF4-eEF1A2/circCTDP1-PFKFB3 axis plays crucial roles in VSMCs phenotypic switching.

2022-11-09 | PXD038057 |

Toxoplasma gondii GT1

Project description:Toxoplasma gondii GT1 Raw sequence reads

| PRJNA812267 | ENA

Effects of Klf4 deletion from Agrp expressing cells under chow or HFD conditions

Project description:Effects of Klf4 deletion from Agrp expressing cells under chow or HFD conditions

| PRJNA933607 | ENA

Effects of CYTOR Knockdown via CRISPRi on K562 cells

Project description:Effects of CYTOR Knockdown via CRISPRi on K562 cells

| PRJNA1201158 | ENA