Prion infected ScN2a and GT1
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Johannes Beckers
PROVIDER: E-GEOD-1803 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Cell line dependent RNA expression profiles of prion-infected mouse neuronal cells.
Greenwood Alex D AD Horsch Marion M Stengel Anna A Vorberg Ina I Lutzny Gloria G Maas Elke E Schädler Sandra S Erfle Volker V Beckers Johannes J Schätzl Hermann H Leib-Mösch Christine C
Journal of molecular biology 20050412 3
The overall impact of prion disease on gene expression is not well characterized. We have carried out a large-scale expression analysis of specific cell types commonly employed in studies of prion disease. Neuroblastoma cells (N2a) and hypothalamic neuronal cells (GT1) can be persistently infected with mouse-adapted scrapie prions, the latter demonstrating cytopathologic effects associated with prion neuropathology. Exploiting a mouse DNA microarray containing approximately 21,000 spotted cDNAs, ...[more]
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