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Time-course transcriptome analysis of TF-induced iPSC neurons

ABSTRACT: Time-course transcriptome analysis of TF-induced iPSC neurons

PROVIDER: PRJNA932343 | ENA |

REPOSITORIES: ENA

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Time-course transcriptome analysis of TF-induced iPSC neurons

Project description:We report on a comprehensive time-course study of transcription factor (TF)-induced iPSC neurons cultured in vitro through an intrinsic maturation program following neurogenesis. Combining the present RNA-seq study with immunocytochemistry and electrophysiological analyses, we determined the transcriptional and morphological sequences of key developmental events associated with postnatal brain-like transition and spinogenesis. TF-induced iPSC neurons successfully acquired structural and functional synaptic maturity, which will critically expand their utility in modeling higher brain functions and disorders.

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