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Changes in molecular profiles of the left ventricle during progressive dilated cardiomyopathy linked heart failure

ABSTRACT: Changes in molecular profiles of the left ventricle during progressive dilated cardiomyopathy linked heart failure

PROVIDER: PRJNA933565 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR23393552_1.fastq.gz	Fastqsanger.gz
	SRR23393552_2.fastq.gz	Fastqsanger.gz
	SRR23393553_1.fastq.gz	Fastqsanger.gz
	SRR23393553_2.fastq.gz	Fastqsanger.gz
	SRR23393554_1.fastq.gz	Fastqsanger.gz

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Methylome analysis reveals alterations in DNA methylation in the regulatory regions of left ventricle development genes in human dilated cardiomyopathy (methylation)

Project description:Alterations in DNA methylation and gene expression have been implicated in the development of human dilated cardiomyopathy (DCM). In this study, we analyzed DNA methylomes (Infinium 450K HumanMethylation BeadChip) and characterize differentially methylated probes between the left and right ventricles Illumina 450K array and HT-12 v4 array for the left, right ventricles

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Project description:We wanted to see whether the set of affected genes in ischemic cardiomyopathy (ICM) is the same or different as compared to dilated cardiomyopathy (DCM). To find this out, we placed the single DCM sample on the same microarray slide with the ICM samples. Analysis of microarray data with ICM samples only showed 63 affected genes, while that carried out with 2 ICM samples PLUS one DCM sample reduced this number to just four genes. From this result we conclude that ICM and DCM affect different sets of genes in ventricular myocytes. Keywords: Expression profiling by array From the associated publication: To find out whether the splice microarray results reported in Table 3 are disease-type specific, we supplemented the same splice microarray of ICM ventricular myocytes with one additional sample prepared from left ventricle of a 41-years old dilated cardiomyopathy male donor. The top-list ANOVA gene score annotation for combined altered CE&P genes in ventricular myocytes (Table 3) was reduced from 63 to just 4 genes (FXYD1 (Gfold = +2.4), HCN2 (-1.5), GLRA1 (-1.8) and GJC1 (-2.3)).

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