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Mast cells link immune sensing to antigen avoidance behavior [stomach]

ABSTRACT: Mast cells link immune sensing to antigen avoidance behavior [stomach]

PROVIDER: PRJNA934580 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR23401500_1.fastq.gz	Fastqsanger.gz
	SRR23401500_2.fastq.gz	Fastqsanger.gz
	SRR23401501_1.fastq.gz	Fastqsanger.gz
	SRR23401501_2.fastq.gz	Fastqsanger.gz
	SRR23401502_1.fastq.gz	Fastqsanger.gz

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Mast cells link immune sensing to antigen avoidance behavior [stomach]

Project description:We investigated antigen-specific avoidance behavior in mice, and found that is critically dependent on mast cells. We analyzed gene expression comparing naive versus immunized wild type mice, and versus mast cell-deficient mice at different times following antigen exposure

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Mast cells link immune sensing to antigen avoidance behavior

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Mast cells link immune sensing to antigen avoidance behavior

Project description:Mast cells link immune sensing to antigen avoidance behavior

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Mast cells link immune sensing to antigen avoidance behavior [intestine]

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Mast cells link immune sensing to antigen avoidance behavior [intestine]

Project description:Mast cells link immune sensing to antigen avoidance behavior [intestine]

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Mast cells link immune sensing to antigen-avoidance behaviour.

Project description:The physiological functions of mast cells remain largely an enigma. In the context of barrier damage, mast cells are integrated in type 2 immunity and, together with immunoglobulin E (IgE), promote allergic diseases. Allergic symptoms may, however, facilitate expulsion of allergens, toxins and parasites and trigger future antigen avoidance1-3. Here, we show that antigen-specific avoidance behaviour in inbred mice4,5 is critically dependent on mast cells; hence, we identify the immunological sensor cell linking antigen recognition to avoidance behaviour. Avoidance prevented antigen-driven adaptive, innate and mucosal immune activation and inflammation in the stomach and small intestine. Avoidance was IgE dependent, promoted by Th2 cytokines in the immunization phase and by IgE in the execution phase. Mucosal mast cells lining the stomach and small intestine rapidly sensed antigen ingestion. We interrogated potential signalling routes between mast cells and the brain using mutant mice, pharmacological inhibition, neural activity recordings and vagotomy. Inhibition of leukotriene synthesis impaired avoidance, but overall no single pathway interruption completely abrogated avoidance, indicating complex regulation. Collectively, the stage for antigen avoidance is set when adaptive immunity equips mast cells with IgE as a telltale of past immune responses. On subsequent antigen ingestion, mast cells signal termination of antigen intake. Prevention of immunopathology-causing, continuous and futile responses against per se innocuous antigens or of repeated ingestion of toxins through mast-cell-mediated antigen-avoidance behaviour may be an important arm of immunity.

| S-EPMC10432277 | biostudies-literature

Transcription profiling of hippocampus samples from the Rattus norvegicus Syracuse High Avoidance (SHA) and Syracuse Low Avoidance (SLA) strains

Project description:Comparisons of hippocampi of Syracuse High Avoidance (SHA) and Syracuse Low Avoidance (SLA) learning rats

2007-10-12 | E-GEOD-932 | biostudies-arrayexpress

Actinomyces oralis strain:stomach | isolate:stomach

Project description:Actinomyces oralis strain:stomach | isolate:stomach Genome sequencing

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Mast Cell Activation

Project description:BACKGROUND: In asthma and other allergic disorders, the activation of mast cells by IgE and antigen induces the cells to release histamine and other mediators of inflammation, as well as to produce certain cytokines and chemokines. To search for new mast cell products, we used complementary DNA microarrays to analyze gene expression in human umbilical cord blood-derived mast cells stimulated via the high-affinity IgE receptor (Fc&straightepsilon;RI). : One to two hours after Fc&straightepsilon;RI-dependent stimulation, more than 2,400 genes (about half of which are of unknown function) exhibited 2-200 fold changes in expression. The transcriptional program included changes in the expression of IL-11 and at least 30 other cytokines and chemokines. Human mast cells secreted 130-529 pg of IL-11/106 cells by 6 h after stimulation with anti-IgE. CONCLUSION: Our initial analysis of the transcriptional program induced in in vitro-derived human mast cells stimulated via the Fc&straightepsilon;RI has identified many products that heretofore have not been associated with this cell type, but which may significantly influence mast cell function in IgE-associated host responses. We also have demonstrated that mast cells stimulated via the Fc&straightepsilon;RI can secrete IL-11. Based on the previously reported biological effects of IL-11, our results suggest that production of IL-11 may represent one link between IgE-dependent mast cell activation in subjects with allergic asthma and the development of a spectrum of structural changes in the airways of these individuals; such changes, collectively termed "airway remodeling," can constitute an important long term consequence of asthma. Set of arrays organized by shared biological context, such as organism, tumors types, processes, etc. Keywords: Logical Set

2005-09-09 | GSE3271 | GEO

Syracuse High/Low Avoidance Learning in Rats

Project description:Comparisons of hippocampi of Syracuse High Avoidance (SHA) and Syracuse Low Avoidance (SLA) learning rats Keywords: other

2003-12-31 | GSE932 | GEO