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Assessing kidney injury induced by mercuric chloride in guinea pigs with in vivo and in vitro experiments

ABSTRACT: Assessing kidney injury induced by mercuric chloride in guinea pigs with in vivo and in vitro experiments

PROVIDER: PRJNA939640 | ENA |

REPOSITORIES: ENA

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Assessing kidney injury induced by mercuric chloride in guinea pigs with in vivo and in vitro experiments [in vivo]

Project description:In this study we tested the ability to predict organ injury from in vivo transcriptomics data in male Hartley guinea pigs at early time points after exposure to mercury chloride (9 and 33 hours). We selected mercury chloride, a compound extensively used in animal studies for its ability to cause acute kidney damage.

2023-05-03 | GSE226312 | GEO

Assessing kidney injury induced by mercuric chloride in guinea pigs with in vivo and in vitro experiments [in vitro]

Project description:Assessing kidney injury induced by mercuric chloride in guinea pigs with in vivo and in vitro experiments [in vitro]

| PRJNA939684 | ENA

Assessing kidney injury induced by mercuric chloride in guinea pigs with in vivo and in vitro experiments [in vivo]

Project description:Assessing kidney injury induced by mercuric chloride in guinea pigs with in vivo and in vitro experiments [in vivo]

| PRJNA939686 | ENA

Assessing kidney injury induced by mercuric chloride in guinea pigs with in vivo and in vitro experiments [in vitro]

Project description:In this study we tested the ability to predict organ injury from in vitro transcriptomics data at early time points after exposure to mercury chloride (12 and 24 hours). We selected mercury chloride, a compound extensively used in animal studies for its ability to cause acute kidney damage.

2023-05-03 | GSE226311 | GEO

Plasma Biomarkers for VX exposure in guinea pigs

Project description:Biomarker discovery using plasma obtained from exposed guinea pigs (N=6) exposed to VX.

2020-08-03 | PXD017254 | Pride

miRNA levels in caput and cauda sperm in adult male guinea pigs following synthetic glucocorticoid exposure

Project description:It has been demonstrated that males exposed to adversity prior to conception sire offspring exhibiting abnormal behaviour and neuroendocrine function. Epigenetic factors such as microRNA (miRNA) within sperm may be responsible for driving these effects. Synthetic glucocorticoids (sGC) are a class of drug that are commonly prescribed and may have implications for intergenerational transmission. Therefore, we hypothesized that caput and cauda sperm miRNA profiles will be altered following sGC exposure in guinea pigs. We used miRNA microarray to evaluate the miRNA levels of caput and cauda sperm isolated from guinea pigs exposed to control and water treated with sGC. We identified a subset of miRNAs with low levels in cauda sperm of guinea pigs exposed to sGC.

2023-03-17 | GSE226168 | GEO

Development of oligonucleotide microarray to study global gene expression profile in guinea pigs in response to tuberculosis infection

Project description:In this study we developed a guinea pig oligonucleotide microarray (GPOM) comprising of a total number of 45,220 features including 43,803 valid features from different mammalian species. These features are inclusive of 2971 newly annotated probes corresponding to 344 unique genes of guinea pig. As a case study, we utilized this array to examine the gene expression profile in guinea pig lungs in response to infection with Mycobacterium tuberculosis. Studying the global gene expression profile in guinea pigs allowed identification of the disease signature of pulmonary TB infection represented by several unique genes that are differentially regulated in this model. While, 1344 unique genes exhibited marked up regulation, 1856 genes were significantly down regulated. The newly developed tool not only finds its utility in studying the global gene expression profile associated with vaccination and/or M. tuberculosis infection in this highly useful animal model but would also be immensely useful in identification of new drug targets, testing of therapies, molecular genetic analysis for diseases other than tuberculosis as well. Genotypic Technology designed Custom Cavia porcellus 4x44k Gene Expression Array (Agilent-AMADID-019424) * In order to validate the GPOM developed in this study, we compared the gene expression profile of guinea pig lungs at 10 weeks post- M. tuberculosis infection with respect to that obtained from normal uninfected animals. To address this, guinea pigs were aerosol infected with M. tuberculosis, lungs were harvested at 10 weeks post-infection and RNA obtained from infected lungs was employed for cDNA synthesis and microarray hybridization. The gene expression was compared with the RNA sample obtained from the lungs of normal uninfected guinea pigs.

2012-10-01 | E-GEOD-32447 | biostudies-arrayexpress

Proteomic study of the retina of guinea pigs with form-deprivation myopia

Project description:Myopia has become the major cause of visual impairment worldwide. However, its retina-related pathogenesis remains unclear. In recent years, proteomics has become a high-throughput tool to explain biological mechanisms. In this study, we examined the retinas of guinea pigs with form deprivation myopia using 4D label-free proteomics and found disorders of retinal metabolism in experimental myopia.

2023-07-12 | PXD043226 | Pride

Assessing kidney injury induced by mercuric chloride in guinea pigs with in vivo and in vitro experiments

Project description:This SuperSeries is composed of the SubSeries listed below.

2023-05-03 | GSE226313 | GEO

miRNA levels in F1-F3 male germ cells and female F2 PFC following prenatal exposure to sGC in guinea pigs

Project description:Stress and glucocorticoid exposure during pregnancy alters neurodevelopment and behavior in offspring, and these effects extend multiple generations through a paternal lineage. The epigenetic mechanisms that govern this transgenerational transmission are unclear. We hypothesized that maternal exposure to multiple courses of sGC in late pregnancy would result in altered miRNA levels in germs cells of male guinea pigs across three generations. Further, our behavioral data indicate that F2 females exhibit altered behaviors following sGC exposure. Thus, we evaluated the miRNA profile of F2 female prefrontal cortex to determine the mechanisms responsible for these behavioral changes and to compare these data to our germ cell miRNA analysis. We used miRNA microarray to evaluate the miRNA levels in F1-F3 germ cells and F2 female PFC in guinea pigs that were exposed to control and F0 prenatal sGC exposure. We identified no significant changes to miRNA levels in both F1-F3 germ cells and F2 PFC from guinea pigs in the sGC group.

2024-01-25 | GSE250055 | GEO

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