Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Molecular profiling of osteoprogenitor cells reveals FOS as a master regulator of bone non-union [tissue]

ABSTRACT: Molecular profiling of osteoprogenitor cells reveals FOS as a master regulator of bone non-union [tissue]

PROVIDER: PRJNA940705 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR23694700_1.fastq.gz	Fastqsanger.gz
	SRR23694700_2.fastq.gz	Fastqsanger.gz
	SRR23694701_1.fastq.gz	Fastqsanger.gz
	SRR23694701_2.fastq.gz	Fastqsanger.gz
	SRR23694702_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 118

Similar Datasets

Molecular profiling of osteoprogenitor cells reveals FOS as a master regulator of bone non-union [tissue]

Project description:Despite the advances in bone fracture treatment, a significant fraction of fracture patients will develop non-union. Most non-unions are treated with surgery since identifying the molecular causes of these defects is exceptionally challenging. In this study, compared with marrow bone, we generated a transcriptional atlas of human osteoprogenitor cells derived from healing callus and non-union fractures. Detailed comparison among the three conditions revealed a substantial similarity of callus and nonunion at the gene expression level. Nevertheless, when assayed functionally, they showed different osteogenic potential. Utilizing longitudinal transcriptional profiling of the osteoprogenitor cells, we identified FOS as a putative master regulator of non-union fractures. We validated FOS activity by profiling a validation cohort of 31 tissue samples. Our work identified new molecular targets for non-union classification and treatment while providing a valuable resource to better understand human bone healing biology.

2024-01-10 | GSE226566 | GEO

Molecular profiling of osteoprogenitor cells reveals FOS as a master regulator of bone non-union [timecourse]

2024-01-10 | GSE226565 | GEO

Molecular profiling of osteoprogenitor cells reveals FOS as a master regulator of bone non-union

Project description:Molecular profiling of osteoprogenitor cells reveals FOS as a master regulator of bone non-union

| PRJNA940702 | ENA

Molecular profiling of osteoprogenitor cells reveals FOS as a master regulator of bone non-union [timecourse]

Project description:Molecular profiling of osteoprogenitor cells reveals FOS as a master regulator of bone non-union [timecourse]

| PRJNA940704 | ENA

Molecular profiling of osteoprogenitor cells reveals FOS as a master regulator of bone non-union

Project description:This SuperSeries is composed of the SubSeries listed below.

2024-01-09 | GSE226568 | GEO

Non-union skeletal fractures

Project description:Non-union skeletal fractures are characterized by their inability to heal six months after injury. Left untreated, the non-union fracture may cause advanced arthritis or loss of function in the affected limb. Arrays were used to identify the mechanisms that lead to lack of skeletal repair in non-unions. These profiles are the non-union callous samples pooled from five individuals Keywords: other

2003-07-16 | GSE494 | GEO

TAp73 is a master regulator of airway multiciliogenesis

Project description:TAp73 is a master regulator of airway multiciliogenesis

| PRJNA305139 | ENA

Transcriptional regulation of the thymus master regulator Foxn1

Project description:Transcriptional regulation of the thymus master regulator Foxn1

| PRJNA793576 | ENA

Transcriptional regulation of the thymus master regulator Foxn1 [RNAseq_AR3_vs_nude]

Project description:Transcriptional regulation of the thymus master regulator Foxn1 [RNAseq_AR3_vs_nude]

| PRJNA793578 | ENA

Identification of a master regulator of differentiation in Toxoplasma

Project description:Identification of a master regulator of differentiation in Toxoplasma