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Whole-body gene expression atlas of an adult metazoan

ABSTRACT: Whole-body gene expression atlas of an adult metazoan

PROVIDER: PRJNA941276 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR24602405.fastq.gz	Fastqsanger.gz
	SRR24602406.fastq.gz	Fastqsanger.gz
	SRR24602407.fastq.gz	Fastqsanger.gz
	SRR24602408.fastq.gz	Fastqsanger.gz
	SRR24602409.fastq.gz	Fastqsanger.gz

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Whole-body gene expression atlas of an adult metazoan

Project description:Animals are integrated organ systems composed of interacting cells whose structure and function are in turn defined by their active genes. Understanding what distinguishes physiological and disease states therefore requires systemic knowledge of the gene activities that define the distinct cells that make up an animal. Towards this goal, this study reports the first single-cell resolution transcriptional atlas of a fertile multicellular organism: Caenorhabditis elegans.

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Whole-body gene expression atlas of an adult metazoan.

Project description:Gene activity defines cell identity, drives intercellular communication, and underlies the functioning of multicellular organisms. We present the single-cell resolution atlas of gene activity of a fertile adult metazoan: Caenorhabditis elegans. This compendium comprises 180 distinct cell types and 19,657 expressed genes. We predict 7541 transcription factor expression profile associations likely responsible for defining cellular identity. We predict thousands of intercellular interactions across the C. elegans body and the ligand-receptor pairs that mediate them, some of which we experimentally validate. We identify 172 genes that show consistent expression across cell types, are involved in basic and essential functions, and are conserved across phyla; therefore, we present them as experimentally validated housekeeping genes. We developed the WormSeq application to explore these data. In addition to the integrated gene-to-systems biology, we present genome-scale single-cell resolution testable hypotheses that we anticipate will advance our understanding of the molecular mechanisms, underlying the functioning of a multicellular organism and the perturbations that lead to its malfunction.

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