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Different immunological mechanisms between AQP4-positive and MOG-positive optic neuritis based on RNA-seq analysis of whole blood

ABSTRACT: Different immunological mechanisms between AQP4-positive and MOG-positive optic neuritis based on RNA-seq analysis of whole blood

PROVIDER: PRJNA941826 | ENA |

REPOSITORIES: ENA

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Different immunological mechanisms between AQP4-positive and MOG-positive optic neuritis based on RNA-seq analysis of whole blood

Project description:To compare the different immunological mechanisms between aquaporin 4 antibody-associated optic neuritis (AQP4-ON) and myelin oligodendrocyte glycoprotein antibody-associated optic neuritis (MOG-ON) based on RNA sequencing (RNA-seq) of whole blood.

2023-03-07 | GSE226808 | GEO

Different immunological mechanisms between AQP4 antibody-positive and MOG antibody-positive optic neuritis based on RNA sequencing analysis of whole blood.

Project description:PurposeTo compare the different immunological mechanisms between aquaporin 4 antibody-associated optic neuritis (AQP4-ON) and myelin oligodendrocyte glycoprotein antibody-associated optic neuritis (MOG-ON) based on RNA sequencing (RNA-seq) of whole blood.MethodsWhole blood was collected from seven healthy volunteers, 6 patients with AQP4-ON and 8 patients with MOG-ON, and used for RNA-seq analysis. An examination of immune cell infiltration was performed using the CIBERSORTx algorithm to identify infiltrated immune cells.ResultsRNA-seq analysis showed that the inflammatory signaling was mainly activated by TLR2, TLR5, TLR8 and TLR10 in AQP4-ON patients, while which was mainly activated by TLR1, TLR2, TLR4, TLR5 and TLR8 in MOG-ON patients. Biological function identification of differentially expressed genes (DEGs) based on Gene Ontology (GO) term and Kyoto encyclopedia of genes and genomes (KEGG) pathway enrichment analysis, as well as Disease Ontology (DO) analysis, showed that the inflammation in AQP4-ON was likely mediated by damage-associated molecular pattern (DAMP), while which in MOG-ON was likely mediated by pathogen-associated molecular pattern (PAMP). Analysis of immune cell infiltration showed that the proportion of immune cell infiltration was related to patients' vision. The infiltration ratios of monocytes (rs=0.69, P=0.006) and M0 macrophages (rs=0.66, P=0.01) were positively correlated with the BCVA (LogMAR), and the infiltration ratio of neutrophils was negatively correlated with the BCVA (LogMAR) (rs=0.65, P=0.01).ConclusionThis study reveals different immunological mechanisms between AQP4-ON and MOG-ON based on transcriptomics analysis of patients' whole blood, which may expand the current knowledge regarding optic neuritis.

| S-EPMC10036921 | biostudies-literature

MOG-expressing teratoma followed by MOG-IgG-positive optic neuritis.

Project description: Not available

| S-EPMC7785547 | biostudies-literature

Zea mays cultivar:MoG

Project description:Zea mays MoG Exome Capture - MoG.3

| PRJNA455910 | ENA

Zea mays cultivar:MoG

Project description:Zea mays MoG Exome Capture - MoG.2

| PRJNA456569 | ENA

MOG KO Tregs versus WT Tregs

Project description:Transcriptional comparison of WT Tregs versus MOG KO Tregs

2016-08-31 | GSE79124 | GEO

Effect of MOG-7 disruption on the C. elegans transcriptome

Project description:In higher eukaryotes, splicing of introns from pre-mRNAs is required for gene expression. Here, we report that Caenorhabditis elegans MOG-7 is a hybrid RNA splicing factor that contains conserved splicing domains from both yeast and mammals. Acute removal of MOG-7 from the C. elegans germline causes intron retention in the majority of genes, resulting in sterility, germline masculinization and germ cell morphology defects. Despite the deleterious consequences caused by MOG-7 loss, the germline can functionally recover to produce viable and fertile progeny once MOG-7 expression is restored through apoptotic clearance of defective germ cells.

2022-04-13 | GSE162055 | GEO

Zea mays cultivar:MoG

Project description:Zea mays cultivar:MoG Genome sequencing

| PRJNA251194 | ENA

Zea mays cultivar:MoG

Project description:Zea mays MoG Exome Capture - 148731

| PRJNA456568 | ENA

Expression data from mouse optic nerve head after optic nerve crush

Project description:Reactive gliosis is a complex process that involves profound changes in gene expression. We used microarray to indentify differentially expressed genes and to investigate the molecular mechanisms of reactive gliosis in optic nerve head in response to optic nerve crush injury. C57Bl/6 female mice were 6-8 weeks old at the time of optic nerve crush surgery. The optic nerve in the left eye was crush 1 mm behind the globe for 10 seconds and the right eye served as contralateral control. The animals were allowed to recover for 1 day, 3 day, 1 week, 3 weeks and 3 months before the optic nerve heads were collected. The naive control mice did not receive any surgery in either eye. Due to the small tissue size of the mouse optic nerve head, two optic nerve heads were pooled together for each microarray chip. The left eyes and the right eyes of two mice were combined respectively to form one pair of experiment and control samples. There were five biological replicates (10 mice) for each condition.

2013-07-15 | E-GEOD-40857 | biostudies-arrayexpress

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