Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Aster asteroides (DC.) O. Ktze.

ABSTRACT: Aster asteroides (DC.) O. Ktze. Raw sequence reads

PROVIDER: PRJNA942096 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR23814682_1.fastq.gz	Fastqsanger.gz
	SRR23814682_2.fastq.gz	Fastqsanger.gz

Items per page:

1 - 2 of 2

Similar Datasets

Aster sampsonii

Project description:Aster sampsonii Raw sequence reads

| PRJNA723149 | ENA

Aster poliothamnus Diels

Project description:Aster poliothamnus Diels Raw sequence reads

| PRJNA946349 | ENA

Aster souliei Franch.

Project description:Aster souliei Franch. Raw sequence reads

| PRJNA942098 | ENA

Aster diplostephioides C. B. Clarke.

Project description:Aster diplostephioides C. B. Clarke. Raw sequence reads

| PRJNA942113 | ENA

Nocardia asteroides

Project description:Nocardia asteroides overview

| PRJNA170216 | ENA

Bifidobacterium asteroides

Project description:Bifidobacterium asteroides overview

| PRJNA83621 | ENA

Cooperation between ASTER-dependent nonvesicular transport and NPC1L1 facilitates dietary cholesterol uptake

Project description:Intestinal cholesterol absorption is an important determinant of systemic cholesterol homeostasis. Niemann-Pick C1 Like 1 (NPC1L1), the target of the drug ezetimibe, is a critical player in dietary cholesterol uptake. But how cholesterol moves within the cell downstream of NPC1L1 is unknown. Here we show that the nonvesicular sterol transporters Aster-B and -C cooperate with NPC1L1 to deliver dietary cholesterol from the gut lumen to the enterocyte ER for chylomicron packaging. Aster proteins are recruited to the enterocyte plasma membrane (PM) in response to NPC1L1-dependent cholesterol accumulation. Mice lacking Asters in intestine have impaired cholesterol absorption, and reduced plasma cholesterol. NanoSIMS imaging and tracer studies reveal delayed lipid trafficking into chylomicrons in Aster-deficient enterocytes. Interestingly, in addition to potently blocking NPC1L1, ezetimibe is also a low-affinity inhibitor of Aster-B and -C but not -A, and the structure of the Aster-C-ezetimibe complex reveals the basis for this selectivity. Our findings support a model in which NPC1L1 enriches dietary cholesterol at the apical PM, and ASTERs subsequently traffic this cholesterol to the ER. The findings identify the enterocyte Aster pathway as potential target for treatment of hypercholesterolemia. Alessandra Ferrari, PhD

2023-12-21 | GSE206780 | GEO

Corydalis DC.

Project description:Phylogeny and diversification of Corydalis DC. Raw sequence reads

| PRJNA1006197 | ENA

Aster

Project description:Transcriptomes of Aster savatieri and Aster savatieri var. pygmaeus (Asteraceae)

| PRJDB3246 | ENA

Thalassianthus aster

Project description:Thalassianthus aster

| PRJNA1138224 | ENA