Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Hi-C profiling of solid tumor samples

ABSTRACT: Hi-C profiling of solid tumor samples

PROVIDER: PRJNA944367 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Hi-C profiling of solid tumor samples

Project description:Hi-C profiling of solid tumor samples

| PRJNA944368 | ENA

Transcription profiling of human pediatric solid tumor cell lines

Project description:For identification of candidate genes that is specifically expressed in Ewing family tumor (EFT) cells, we performed DNA microarray-based global expression profiling using Affymetrix Human Genome U133 Plus 2.0 Array and analyxed expression profiles from EFT cell lines (7 lines), neuroblastoma (NB) cell lines (3 lines), a Rhabdomyosarcoma (RMS) cell line, and a human immortalized mesenchymal progenitor cells UET-13 cells. Experiment Overall Design: Expression profiles of pediatric solid tumor cell lines were analyzed and compared using Affymetrix HG-U133 Plus 2.0 (GPL570).

2008-06-16 | E-GEOD-8596 | biostudies-arrayexpress

Tracing tumorigenesis in a solid tumor model at single-cell resolution

Project description:Characterizing the complex composition of solid tumors is fundamental for understanding tumor initiation, progression and metastasis. While patient-derived samples provide valuable insight, they are heterogeneous on multiple molecular levels, and often originate from advanced tumor stages. Here, we use single-cell transcriptome and epitope profiling together with pathway and lineage analyses to study tumorigenesis from a developmental perspective in a mouse model of salivary gland squamous cell carcinoma. We provide a comprehensive cell atlas and characterise tumor-specific cells. We find that these cells are connected along a reproducible developmental trajectory: initiated in basal cells exhibiting an epithelial-to-mesenchymal transition signature, tumorigenesis proceeds through Wnt-differential cancer stem cell-like subpopulations before differentiating into luminal-like cells. Our work provides unbiased insights into tumor-specific cellular identities in a whole tissue environment and emphasizes the power of using defined genetic model systems.

2020-02-20 | GSE124425 | GEO

Myeloid amino acid metabolism supports solid tumor malignancy

Project description:Myeloid amino acid metabolism supports solid tumor malignancy

| PRJNA518914 | ENA

Genomic Profiling in Cancer Patients (Breast Cancer Paired Tumor Samples)

Project description:Genomic Profiling in Cancer Patients (Breast Cancer Paired Tumor Samples)

| PRJNA487832 | ENA

Genomic Profiling in Cancer Patients (Breast Cancer Paired Tumor Samples)

Project description:Genomic Profiling in Cancer Patients (Breast Cancer Paired Tumor Samples)

| PRJNA487831 | ENA

Differential effects of antofine N-oxide on solid tumor and leukemia cells

Project description:We have studied the anti-cancer activities of antofine N-oxide isolated and purified from the medicinal plant Cynanchum vincetoxicum. The compound displays a strong cytotoxic effect on several solid tumor cell lines (glioblastoma, breast carcinoma and lung carcinoma) and on T-cell leukemia. It induces cytostasis in the solid tumor cell lines whereas it causes apoptotic cell death in the leukemia cell line. The cytotoxic effect is much weaker in non-cancer control cells. A microarray analysis of the gene expression after a short treatment showed a set of differentially expressed genes in the two types of cancer cells (apoptosis versus cytostasis). Interestingly, a number of genes of the TNF-alpha signaling pathway are up-regulated in the three solid tumor cell lines, including TNF-alpha which is among the most significantly up-regulated genes. The increased TNF-alpha, TNFAIP3 and BIRC3 mRNA levels were further confirmed after different treatment durations by real-time quantitative PCR (qPCR). Our results suggest that inhibition of cell proliferation in solid tumor cells essentially occurs through TNF-alpha signaling whereas no conclusion could be drawn concerning the pathways leading to apoptotic cell death in leukemia cells due to the reduced number of differentially expressed genes.ﾔ

2014-09-23 | E-MTAB-1900 | biostudies-arrayexpress

Buried solid waste samples in capped and uncapped areas

Project description:Buried solid waste samples in capped and uncapped areas Metagenome

| PRJNA837104 | ENA

CCOGC canine Osteosarcoma tumor samples

Project description:CCOGC canine Osteosarcoma tumor samples

| PRJNA1001809 | ENA