Project description:This SuperSeries is composed of the following subset Series: GSE28204: mRNA expression profile in PCa And BPH from Chinese patients GSE34932: miRNA expression profile in PCa And BPH tissue from Chinese patients Refer to individual Series
Project description:Chinese medicine is a complex system guided by traditional Chinese medicine (TCM) theories, which has proven to be especially effective in treating chronic and complex diseases. However, the underlying modes of action (MOA) are not always systematically investigated. Herein, a systematic study was designed to elucidate the multi-compound, multi-target and multi-pathway MOA of a Chinese medicine ,QSYQ, on myocardial infarction. Male Sprague Dawley rat model of myocardial infarction were administered QSYQ intragastrically for 7 days while the control group was not treated. The differentially expressed genes (DEGs) were identified from myocardial infarction rat model treated with QSYQ, followed by constructing a cardiovascular disease (CVD)-related multilevel compound-target-pathway network connecting main compounds to those DEGs supported by literature evidences and the pathways that are functionally enriched.
Project description:Using high-throughput antibody microarray, through cross-sectional sample detection and verification of samples that had undergone physical changes over time, it was found that people with balanced constitution and dampness constitution in Chinese medicine showed differences in serum protein expression. The differences were expressed as the level changes of 19 proteins such as Dectin-2, Siglec-7, AIF and TACI. The research results provided the basis for the scientific expression of traditional Chinese medicine (TCM) constitution.
Project description:Traditional Chinese medicine Jinfukang (JFK) has been used for lung cancer treatment for more than ten years, however, the mechanism is not well understood. Previously we showed that JFK inhibited survival of a human lung cell line A459 via cell apoptosis and inducing cell cycle arrest. To better understand the mechanism, we performed ChIP-seq assays to evaluate the effect of JFK on genome-wide profiling of H3K4Me3 modification.
Project description:Potentilla indica and Melastoma dodecandrum lour are medicinal herbs used in traditional Chinese medicine. We sampled the plants from Nanyang Technological University's herb garden for transcriptomics analysis.