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Human serous cavity macrophages and dendritic cells possess counterparts in the mouse with a distinct distribution between species

ABSTRACT: Human serous cavity macrophages and dendritic cells possess counterparts in the mouse with a distinct distribution between species

PROVIDER: PRJNA947843 | ENA |

REPOSITORIES: ENA

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Human serous cavity macrophages and dendritic cells possess counterparts in the mouse with a distinct distribution between species

Project description:In mouse peritoneal and other serous cavities, the transcription factor Gata6 drives the identity of the major cavity resident population of macrophages, with a smaller subset of cavity-resident macrophages dependent on the transcription factor Irf4. Here we showed that GATA6+ macrophages in the human peritoneum were rare, regardless of age. Instead, more human peritoneal macrophages aligned with mouse CD206+ LYVE1+ cavity macrophages that represent a differentiation stage just preceding expression of Gata6. Low abundance of CD206+ macrophages was retained in C57BL/6J mice fed a high-fat diet or in wild-captured mice, suggesting that differences between serous cavity-resident macrophages in humans and mice were not environmental. Irf4-dependent mouse serous cavity macrophages aligned closely with human CD1c+CD14+CD64+ peritoneal cells that, in turn, resembled human peritoneal CD1c+CD14-CD64- cDC2. Thus, major populations of serous cavity-resident mononuclear phagocytes in humans and mice shared common features but the proportions of different macrophage differentiation stages greatly differ between the two species and DC2-like cells were especially prominent in humans.

2023-10-17 | GSE228030 | GEO

Krüppel-like Factor family members control expression of genes required for serous cavity and alveolar macrophage identities [RNA-seq]

Project description:Tissue-resident macrophages adopt distinct gene expression profiles and exhibit functional specialization based on their tissue of residence. Recent studies have begun to define the signals and transcription factors that induce these identities. Here we describe an unexpected and specific role for the broadly expressed transcription factor Kruppel-like Factor 2 (KLF2) in the development of embryonically derived Large Cavity Macrophages (LCM) in the serous cavities. KLF2 not only directly regulates the transcription of genes previously shown to specify LCM identity, such as retinoic acid receptors and GATA6, but also is required for induction of many other transcripts that define the identity of these cells. We identify a similar role for KLF4 in regulating the identity of alveolar macrophages in the lung. These data demonstrate that broadly expressed transcription factors, such as Group 2 KLFs, can play important roles in the specification of distinct identities of tissue-resident macrophages.

2025-02-19 | GSE288281 | GEO

Krüppel-like Factor family members control expression of genes required for serous cavity and alveolar macrophage identities [CUT&Run]

2025-02-19 | GSE288282 | GEO

Oral cavity

Project description:Oral cavity Targeted loci

| PRJNA622970 | ENA

oral cavity

Project description:oral cavity Raw sequence reads

| PRJNA953964 | ENA

Human oral cavity

Project description:Human oral cavity microbiota

| PRJNA918786 | ENA

Human sinonasal cavity

Project description:Human sinonasal cavity Targeted loci environmental

| PRJNA407725 | ENA

Ovarian serous cancer

Project description:Ovarian serous cancer

| PRJNA117359 | ENA

Krüppel-like Factor family members control expression of genes required for serous cavity and alveolar macrophage identities [CUT&Run]

Project description:Krüppel-like Factor family members control expression of genes required for serous cavity and alveolar macrophage identities [CUT&Run]

| PRJNA1216669 | ENA

Krüppel-like Factor family members control expression of genes required for serous cavity and alveolar macrophage identities [RNA-seq]

Project description:Krüppel-like Factor family members control expression of genes required for serous cavity and alveolar macrophage identities [RNA-seq]

| PRJNA1216670 | ENA

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