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SETD7 promotes lateral plate mesoderm formation by modulating the Wnt/b-catenin signaling pathway

ABSTRACT: SETD7 promotes lateral plate mesoderm formation by modulating the Wnt/b-catenin signaling pathway

PROVIDER: PRJNA949202 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR23980262_1.fastq.gz	Fastqsanger.gz
	SRR23980262_2.fastq.gz	Fastqsanger.gz
	SRR23980263_1.fastq.gz	Fastqsanger.gz
	SRR23980263_2.fastq.gz	Fastqsanger.gz
	SRR23980264_1.fastq.gz	Fastqsanger.gz

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SETD7 promotes lateral plate mesoderm formation by modulating the Wnt/b-catenin signaling pathway

Project description:Investigating the role of SETD7 during human hematopoietic development

2023-09-11 | GSE228287 | GEO

<i>SETD7</i> promotes lateral plate mesoderm formation by modulating the Wnt/β-catenin signaling pathway.

Project description:The role of SET domain containing 7 (SETD7) during human hematopoietic development remains elusive. Here, we found that deletion of SETD7 attenuated the generation of hematopoietic progenitor cells (HPCs) during the induction of hematopoietic differentiation from human embryonic stem cells (hESCs). Further analysis specified that SETD7 was required for lateral plate mesoderm (LPM) specification but dispensable for the generation of endothelial progenitor cells (EPCs) and HPCs. Mechanistically, rather than depending on its histone methyltransferase activity, SETD7 interacted with β-catenin at lysine residue 180 facilitated its degradation. Diminished SETD7 expression led to the accumulation of β-catenin and the consequent activation of the Wnt signaling pathway, which altered LPM patterning and facilitated the production of paraxial mesoderm (PM). Taken together, the findings indicate that SETD7 is related to LPM and PM patterning via posttranslational regulation of the Wnt/β-catenin signaling pathway, providing novel insights into mesoderm specification during hematopoietic differentiation from hESCs.

| S-EPMC10291335 | biostudies-literature

Development of the chicken lateral plate mesoderm and forelimb mesenchyme

Project description:Development of the chicken lateral plate mesoderm and forelimb mesenchyme

| PRJNA878680 | ENA

Development of the chicken lateral plate mesoderm and forelimb mesenchyme

Project description:The lateral plate mesoderm (LPM) is a transient tissue that produces a diverse range of differentiated structures, including the limbs. However, the molecular mechanisms that drive early LPM specification and development are poorly understood. In this study, we utilize single-cell transcriptomics to define the cell-fate decisions directing LPM specification, subdivision, and early initiation of the forelimb mesenchyme in chicken embryos. We establish a transcriptional atlas and global cell-cell signalling interactions in progenitor, transitional and mature cell types throughout the developing forelimb field.

2022-09-13 | GSE212985 | GEO

Expression profiling of retinoic acid targets in lateral mesoderm from Xenopus laevis embryos

Project description:Renal precusors of the Xenopus pronephros arise from dorso-lateral mesoderm at the early neurula stage. This process is under the control of retinoic acid (RA). We have used microarrays to identify RA targets in dorso-latearl mesoderm by performing differential expression analysis between control and RA-depleted situations

2022-06-13 | GSE205827 | GEO

Differential expression between floor plate and ventral lateral region in E10.5 mouse embryo midbrain

Project description:The data revealed differential expression between floor plate and ventral lateral region in E10.5 mouse embryo midbrain. Several differentially expressed genes in these regions have been reported in the literature, demonstrating reliability of tissue dissection. Midbrain floor plate and non-overlapping adjacent ventral lateral region of mouse E10.5 embryo midbrain was dissected. Each sample was a pool from 6 embryos. Three replicates for each region were used for the experiment.

2011-05-18 | E-GEOD-25178 | biostudies-arrayexpress

Differential expression between floor plate and ventral lateral region in E10.5 mouse embryo midbrain

2011-05-18 | GSE25178 | GEO

Neural induction by the node and placode induction by head mesoderm share an initial state resembling neural plate border

Project description:Purpose: The goal of this study is to identify similarities and differences in the induction of the central nervous system and the sensory placodes in chick. Method: mRNA profiles for central and anterior pre-steak epiblast, neural plate, anterior and posterior pre-placodal region, non-neural epiblast, gastrula stage area opaca exposed to Hensen's node for 5 hours and control area of opaca from the same stage. Deep sequencing was carried with Illumina HiSeq 2000. After filtering low quality reads, alignment was carried using TopHat2, differential expression analysis was done using R-package (easyRNA-seq and DSEq). Results: Despite the differences in inducing tissues (i.e. node and lateral head mesoderm) and in the final outcome (neural plate and pre-placodal region), the initial set of genes induced by both tissues is largely identical. We define this transcriptional signature as 'pre-neural state', and demonstrate its functional significance for both inductive processes. An unbiased approach using GENEI3 and community clustering reveals the gene regulatory modules characterising the transcirptional states of pre-neural, neural and placodal cells. Conclusion: Induction of the neural plate and the pre-placodal region initially share common features, and diverge later. The pre-neural state is similar to the neural plate border and pre-streak epiblast state.

2018-02-14 | GSE106346 | GEO

Eye primordia vs. posterior neural plate vs. lateral endoderm normalized the whole embryos

Project description:Tissues from the eye primordia, lateral endoderm, and posterior neural plate of stage 15 Xenopus laevis embryos were isolated and normalized to stage 15 whole embryos. Three biological replicates were prepared for each tissue and the expression patterns were profiled using Affymetrix Xenopus Laevis GeneChip microarrays. Keywords: Three way comparison of Embryonic Tissue Isolation

2009-08-19 | GSE9175 | GEO

Lateral mesoderm-derived mesenchymal stem cells with robust osteochondrogenic potential and hematopoiesis supporting ability

Project description:Here, hiPSCs were induced to differentiate to mesenchymal stem cells (MSCs) through the intermediate stage of lateral mesoderm (LM). We sequenced mRNA samples of LM and LM-MSCs to generate the gene expression profiles of these cells.

2022-01-19 | GSE182161 | GEO

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