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Engrailed-1 Promotes Pancreatic Cancer Metastasis [RNA-Seq]

ABSTRACT: Engrailed-1 Promotes Pancreatic Cancer Metastasis [RNA-Seq]

PROVIDER: PRJNA951668 | ENA |

REPOSITORIES: ENA

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Engrailed-1 Promotes Pancreatic Cancer Metastasis

Project description:Engrailed-1 Promotes Pancreatic Cancer Metastasis

| PRJNA951660 | ENA

Engrailed-1 Promotes Pancreatic Cancer Metastasis [CUT&RUN]

Project description:Engrailed-1 Promotes Pancreatic Cancer Metastasis [CUT&RUN]

| PRJNA951669 | ENA

Engrailed-1 Promotes Pancreatic Cancer Metastasis [RNA-Seq]

Project description:Engrailed-1 (EN1) is a critical homeodomain transcription factor (TF) required for neuronal survival, and EN1 expression has been shown to promote aggressive forms of triple negative breast cancer. Here, we report that EN1 is aberrantly expressed in a subset of pancreatic ductal adenocarcinoma (PDA) patients with poor outcomes. EN1 predominantly repressed its target genes through direct binding to gene enhancers and promoters, implicating a role in the cellular response to the stimulation of mesenchymal cell properties. Gain- and loss-of-function experiments demonstrated that EN1 promoted PDA transformation and metastasis in vitro and in vivo. Our findings nominate the targeting of EN1 and downstream pathways in aggressive PDA.

2023-12-19 | GSE228804 | GEO

Engrailed-1 Promotes Pancreatic Cancer Metastasis [CUT&RUN]

2023-12-19 | GSE228802 | GEO

Enhancer reprogramming promotes pancreatic cancer progression and metastasis

Project description:Enhancer reprogramming promotes pancreatic cancer progression and metastasis

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Methionine oxidation of PKM2 promotes pancreatic cancer metastasis

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Enhancer reprogramming promotes pancreatic cancer progression and metastasis [ChIP-seq]

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Enhancer reprogramming promotes pancreatic cancer progression and metastasis [RNA-seq]

Project description:Enhancer reprogramming promotes pancreatic cancer progression and metastasis [RNA-seq]

| PRJNA388127 | ENA

Methionine oxidation of PKM2 promotes pancreatic cancer metastasis

Project description:We report that MSRA is a potent suppressor of pancreatic cancer metastasis. We performed global RNA sequencing to examine the transcriptome of pancreatic cancer cells that are proficient or deficient of MSRA

2022-07-19 | GSE179279 | GEO

RHAMMB promotes metastasis of pancreatic neuroendocrine tumor

Project description:RHAMMB promotes metastasis of pancreatic neuroendocrine tumor

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