Ontology highlight
ABSTRACT:
PROVIDER: PRJNA95203 | ENA |
REPOSITORIES: ENA
Similar Datasets
Project description:This SuperSeries is composed of the following subset Series: GSE4052: Near Naked Hairless mouse skin array GSE4053: ORNL 5wk Hr(n)/+ mice skin array GSE4055: ORNL Hr(Rh-R) mouse cutaneous array Keywords: SuperSeries Refer to individual Series
2010-07-01 | E-GEOD-4059 | biostudies-arrayexpress
Project description:This is the data from 7 day-old homozygous Hrn mutant mice compared to the wild type mice with mouse 22k compugen oligolibrary 2.0. The data was normalized with GeneSight from BioDiscovery and analyzed with SAM. Keywords: Genetic mutant 7 day-old near naked hairless mutant mice vs 7 day-old wild type mice. Five biological replicates were used from one litter. Dye-swapping was done to remove dye-specific errors
2010-07-01 | E-GEOD-4052 | biostudies-arrayexpress
Project description:These data is from 10 day-old Hr(Rh-R)/Hr(Rh-R) vs Hr(Rh-R)/+ mice. Mouse 15k microarray from the Center for Applied Genomics was used to survey the gene expression. The data was acquired with ImaGene and processed with GeneSight from BioDiscovery. Keywords: Genetic mutants
2006-04-18 | GSE4055 | GEO
Project description:These data is from 10 day-old Hr(Rh-R)/Hr(Rh-R) vs Hr(Rh-R)/+ mice. Mouse 15k microarray from the Center for Applied Genomics was used to survey the gene expression. The data was acquired with ImaGene and processed with GeneSight from BioDiscovery. Keywords: Genetic mutants Three pairs of littermates from one liter, 10 day-old Hr(Rh-R)/Hr(Rh-R) vs Hr(Rh-R)/+ mice, were used for the hybridization. Dye-swapping was done for each pair of littermates.
2010-07-01 | E-GEOD-4055 | biostudies-arrayexpress
Project description:Mice with the spontaneous uncv mutation are hairless. We utilize the uncv null mouse to investigate the underlying mechanisms giving rise to the relevant phenotypes and reveal significant changes in certain signaling pathways by microarray. Experiment Overall Design: Dorsal skins were taken from 4-day-old uncv null mice and wild type mice (as control), and they are sisters-german. The parent is uncv heterozygosis(uncv +/-), and their children has 3 genotype: wild(uncv +/+), heterozygosis(uncv +/-) and null (uncv -/-). We can easily distinguish them by their beard length and shape or identify their genotype by PCR using specific primers. HR 02 is a wild mouse sample and uncv null mice expresses as HR 03 and HR 04. RNA isolation was performed with the QIAGEN RNeasy mini kit (QIAGEN, Valencia, CA, USA) following standard instructions.
2008-06-16 | E-GEOD-9766 | biostudies-arrayexpress
Project description:Skeletal muscle possesses remarkable regenerative ability owing to the resident muscle stem cells (MuSCs). A prominent feature of quiescent MuSCs is a high content of heterochromatin. However, little is known about the mechanisms by which heterochromatin is maintained in MuSCs. We found that the mammalian Hairless (Hr) gene is expressed in quiescent MuSCs. Using a mouse model in which Hr can be specifically ablated in MuSCs, we demonstrate that Hr expression is critical for MuSC function and muscle regeneration. We show that Hr is a histone demethylase antagonist that preserves Histone 3 Lysine 9 trimethylation (H3K9me3) and maintains heterochromatin structure. Loss of Hr results in reduced H3K9me3 levels, reduced heterochromatin, increased susceptibility of MuSCs to genotoxic stress, and the accumulation of DNA damage. Our study not only elucidates the molecular mechanism by which Hr regulates histone demethylases, but also demonstrates the importance of heterochromatin maintenance in stem cell function.
2021-09-09 | GSE132220 | GEO
Project description:Skeletal muscle possesses remarkable regenerative ability owing to the resident muscle stem cells (MuSCs). A prominent feature of quiescent MuSCs is a high content of heterochromatin. However, little is known about the mechanisms by which heterochromatin is maintained in MuSCs. We found that the mammalian Hairless (Hr) gene is expressed in quiescent MuSCs. Using a mouse model in which Hr can be specifically ablated in MuSCs, we demonstrate that Hr expression is critical for MuSC function and muscle regeneration. We show that Hr is a histone demethylase antagonist that preserves Histone 3 Lysine 9 trimethylation (H3K9me3) and maintains heterochromatin structure. Loss of Hr results in reduced H3K9me3 levels, reduced heterochromatin, increased susceptibility of MuSCs to genotoxic stress, and the accumulation of DNA damage. Our study not only elucidates the molecular mechanism by which Hr regulates histone demethylases, but also demonstrates the importance of heterochromatin maintenance in stem cell function.
2021-09-09 | GSE132189 | GEO
Project description:Analysis of the Naked mole-rat proteome relative to mice
2020-12-18 | MSV000086617 | MassIVE