Project description:The goal of this study is to identify downstream pathways, diagnostic markers, and potential therapeutic targets for IFS/CMN. Global gene expression of 14 cellular mesoblastic nephromas/infantile fibrosarcoma was compared with 10 RT, 16 clear cell sarcomas of the kidney, and 15 Wilms tumors using Affymetrix U133A arrays to identify genetic pathways that clarify the pathogenesis of Rhabdoid Tumors and to discover new therapeutic targets for these tumors
Project description:We detected DNA methylation of a fibrosarcoma with ESCC sample and the corresponding normal sample to identify the aberrant DNA methylation status in this rare disease.
Project description:This study uses microarray analysis to examine the fate of multiple C-ion-irradiated tumors in vivo to gain a comprehensive overview of the changes in gene expression induced by C-ion irradiation. Four murine tumors were irradiated in vivo with C-ions at a single dose, and gamma-rays were used as a reference beam. Keywords: mouse squamous cell carcinoma and fibrosarcoma, carbon ion-irradiation, gamma-irradiation, resected sample, transplanted tissues
Project description:The study focuses on understanding the transcriptional changes and the pathways altered when human cancer (fibrosarcoma ) cells are subjected to telomere elongation.