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Gene expression profile at single cell level of CD45+ cells from subcutaneous implanted fibrosarcoma tumors in T cell depleted Bach1 deficient mice.

ABSTRACT: We used scRNAseq to characterize the CD45+ cell population diversity in fibrosarcoma in T cell depleted Bach1-deficient mice.

ORGANISM(S): Mus musculus

PROVIDER: GSE268866 | GEO | 2024/08/30

REPOSITORIES: GEO

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Gene expression profile at single cell level of CD45+ cells from subcutaneous implanted fibrosarcoma tumors in T cell depleted Bach1 deficient mice.

Project description:Gene expression profile at single cell level of CD45+ cells from subcutaneous implanted fibrosarcoma tumors in T cell depleted Bach1 deficient mice.

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Gene expression data from 1833 cells and 1833 cells depleted of BACH1 mRNA expression

Project description:The transcription factor BACH1 is a master regulator of human breast cancer metastasis. Here we use gene expression array analysis to identify and compare the genes regulated by BACH1 depletion in a metastatic human breast cancer cell line. Total RNAs were extracted from vector control 1833 cells or 1833 cells with shBACH mRNA BACH1 depletion. Affymetrix GeneChip Human Gene 1.0 ST Arrays were performed to detail the gene expression and identify the genes regulated by BACH1in metastatic human breast cancer cells.

2013-10-31 | E-GEOD-50226 | biostudies-arrayexpress

CD45+ vs CD45- RCC proteome characterization

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Gene expression profile at single cell level of iron positive and iron negative cells from subcutaneous implanted syngeneic fibrosarcoma tumors in C57BL/6 mice.

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Gene expression profile at single cell level of cells from subcutaneous implanted syngeneic fibrosarcoma tumors in C57BL/6 mice injected with autologous erythrocytes suspended in buffered saline

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Genome-wide map of BACH1 binding in HEK 293T cells

Project description:BTB and CNC homology 1 (BACH1) is a heme-binding transcription factor repressing the transcription from a subset of MAF recognition elements (MAREs) at low intracellular heme levels. Upon heme binding, BACH1 is released from the MAREs, resulting in increased expression of antioxidant response genes. To systematically address the gene regulatory networks involving BACH1, we combined chromatin immunoprecipitation-sequencing (ChIP-seq) analysis of BACH1 target genes in HEK 293 cells with knock-down of BACH1 using three independent types of small interfering RNAs followed by transcriptome profiling using microarrays. The 59 BACH1 target genes identified by ChIP-seq were found highly enriched in genes showing expression changes after BACH1 knock-down, demonstrating the impact of BACH1 repression on transcription. In addition to known and new BACH1 targets involved in heme degradation (HMOX1, FTL, FTH1, ME1, SLC48A1) and redox regulation (GCLC, GCLM, SLC7A11), we also discovered BACH1 target genes effecting cell cycle and apoptosis pathways (ITPR2, CALM1, SQSTM1, TFE3, EWSR1, CDK6, BCL2L11, MAFG) as well as subcellular transport processes (CLSTN1, PSAP, MAPT, vault RNA). The newly identified impact of BACH1 on genes involved in neurodegenerative processes and proliferation provides an interesting basis for future dissection of BACH1-mediated gene repression in neurodegeneration and virus-induced cancerogenesis. Examination of BACH1 binding in HEK 293T cells by chromatin immunoprecipitation-sequencing (CHIP-seq) with input DNA as control.

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Role of BACH1 in HEK 293T cells

Project description:This SuperSeries is composed of the following subset Series: GSE28050: Expression data from knockdown of BACH1 in HEK 293T cells GSE28051: Genome-wide map of BACH1 binding in HEK293T cells Refer to individual Series

2011-05-12 | E-GEOD-28053 | biostudies-arrayexpress

Dual BACH1 regulation by complementary SCF-type E3 ligases

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2024-12-03 | PXD051074 | Pride

Regulation of immunity by Bach1 in Mice

Project description:Genes regulated by Bach1 transcription factor

2012-07-09 | E-MEXP-3674 | biostudies-arrayexpress