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Granulosa cell-derived serum TNF-α mediates inflammation and apoptosis in renal tubular cells through NF-κB signaling and indicates PCOS-related kidney injury.

ABSTRACT: Granulosa cell-derived serum TNF-α mediates inflammation and apoptosis in renal tubular cells through NF-κB signaling and indicates PCOS-related kidney injury.

PROVIDER: PRJNA952917 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR24092251_1.fastq.gz	Fastqsanger.gz
	SRR24092251_2.fastq.gz	Fastqsanger.gz
	SRR24092252_1.fastq.gz	Fastqsanger.gz
	SRR24092252_2.fastq.gz	Fastqsanger.gz
	SRR24092253_1.fastq.gz	Fastqsanger.gz

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Granulosa cell-derived serum TNF-α mediates inflammation and apoptosis in renal tubular cells through NF-κB signaling and indicates PCOS-related kidney injury.

Project description:Serum TNF-α plays a key role in mediating inflammation and apoptosis in renal tubular cells and indicates PCOS-related kidney injury.

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Project description:Our study is based on the hypothesis that PCOS can be explained by an integrated, epigenetic model, whereby environmental factors modify the effect of susceptibility genes and influence the clinical heterogeneity that is characteristic of the syndrome during adult life. With the aim to understand the molecular mechanisms underlying PCOS, we report results from a case-control, genome-wide methylation study using human DNA from granulosa lutein cells.

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