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Gene expression in diabetic RIP-LCMV-GP mice

ABSTRACT: Gene expression in diabetic RIP-LCMV-GP mice

PROVIDER: PRJNA953965 | ENA |

REPOSITORIES: ENA

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Gene expression in diabetic RIP-LCMV-GP mice

Project description:Gene expression profile in laser-dissected islets of Langerhans in the inducible RIP-LCMV-GP mouse model for type 1 diabetes (T1D) RIP-LCMV-GP mice express the glycoprotein (GP) of the lymphocytic choriomeningitis virus (LCMV) in the beta-cells (rat insulin promotor, RIP); T1D develops 10-14 after LCMV-infection

2023-10-01 | GSE229287 | GEO

NK cell regulation of T cells following LCMV infection of vaccinated and unvaccinated mice

Project description:NK cells may provide a “rheostat” function and have been shown to reduce the magnitude of antigen-specific T cell responses following infection. It remains unknown whether NK cells similarly modulate vaccine-elicited T cell responses following viral challenge. We used the LCMV clone 13 infection model to address whether NK cells regulate T cell responses in Adenovirus vector vaccinated mice following challenge. As expected, NK cell depletion in unvaccinated mice resulted in increased virus-specific CD4+ and CD8+ T cell responses and immunopathology following LCMV challenge. In contrast, NK cell depletion had minimal to no impact on antigen-specific T cell responses in mice that were vaccinated with an Ad5-GP vector prior to LCMV challenge. Moreover, NK cell depletion in vaccinated mice prior to challenge did not result in immunopathology and did not compromise protective efficacy. These data suggest that Adenovirus vaccine-elicited T cells may be less sensitive to NK cell-rheostat regulation than are T cells primed by LCMV infection.

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Comparison of Trail+/+ versus Trail-/- splenic NK cells from naïve and LCMV-infected mice

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Comparison of monocytic cells from naïve mice and day 14 LCMV Armstrong and day 14 LCMV Clone 13 infected mice

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2013-02-25 | GSE43896 | GEO

Gene expression profile analysis of mouse whole spleen following infection by lymphocytic choriomeningitis virus (LCMV), comparing LCMV-Armstrong and LCMV-Clone 13 expression patterns at 0, 5, 9, and 30 days

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Expression data from pancreatic islets from Men1flf RIP-Cre mice, Rbp2flf RIP-Cre mice, Men1flf Rbp2flf RIP-Cre mice and matched control.

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LCMV infection of Sod1-/- vs. WT mice

Project description:LCMV infection of Sod1-/- vs. WT mice

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Pair-feeding of LCMV Cl13 infected mice

Project description:Pair-feeding of LCMV Cl13 infected mice

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