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RNA-sequencing analysis of lung tissue from monocrotaline-induced pulmonary arterial hypertension rats

ABSTRACT: RNA-sequencing analysis of lung tissue from monocrotaline-induced pulmonary arterial hypertension rats

PROVIDER: PRJNA954273 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR24127914_1.fastq.gz	Fastqsanger.gz
	SRR24127914_2.fastq.gz	Fastqsanger.gz
	SRR24127915_1.fastq.gz	Fastqsanger.gz
	SRR24127915_2.fastq.gz	Fastqsanger.gz
	SRR24127916_1.fastq.gz	Fastqsanger.gz

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RNA-sequencing analysis of lung tissue from monocrotaline-induced pulmonary arterial hypertension rats

Project description:To investigate the genes associated with the progression pulmonary arterial hypertension，lung tissues of rats treated either with PBS buffer or monocrotaline (50mg/kg）were harvested for RNA-sequencing.

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Project description:Inflammation and immunity play a causal role in the pathogenesis of pulmonary vascular remodeling and pulmonary arterial hypertension (PAH). However, the pathways and mechanisms by which inflammation and immunity contribute to pulmonary vascular remodeling remain unknown. RNA sequencing was used to analyze the transcriptome in control and rats injected with monocrotaline (MCT) for 1, 2, 3 and 4 weeks. Using the transcriptional profiling of MCT-induced PAH coupled with bioinformatics analysis, we clustered the differentially expressed genes (DEGs) and chose the increased expression patterns associated with inflammatory and immune response. We found the enrichment of Toll-like receptor (TLR) and NOD-like receptor (NLR) pathways and identified NF-κB-mediated inflammatory and immune profiling in MCT-induced PAH. Pathway-based data integration and visualization showed the dysregulated TLR and NLR pathways, including increased expression of TLR2 and NLRP3, and their downstream molecules. Further analysis revealed that the activation of TLR and NLR pathways was associated with upregulation of damage-associated molecular patterns (DAMPs) and RIPK3-mediated necroptosis was involved in the generation of DAMPs in MCT-induced PAH. Collectively, we identify RIPK3-mediated necroptosis and its triggered TLR and NLR pathways in the progression of pulmonary vascular remodeling, thus, providing novel insights into the mechanisms underlying inflammation and immunity in the pathogenesis of PAH.

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