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Multicellular liver organoid model for recapitulating hepatitis C virus infection and non-alcoholic fatty liver disease progression [scRNA-Seq]

ABSTRACT: Multicellular liver organoid model for recapitulating hepatitis C virus infection and non-alcoholic fatty liver disease progression [scRNA-Seq]

PROVIDER: PRJNA955148 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR24153023.fastq.gz	Fastqsanger.gz
	SRR24153024.fastq.gz	Fastqsanger.gz
	SRR24153025.fastq.gz	Fastqsanger.gz
	SRR24153026.fastq.gz	Fastqsanger.gz
	SRR24153027.fastq.gz	Fastqsanger.gz

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Multicellular liver organoid model for recapitulating hepatitis C virus infection and non-alcoholic fatty liver disease progression [scRNA-Seq]

Project description:Hepatitis C virus (HCV) infection has been successfully managed by anti-viral therapies, however, high prevalence to severe chronic liver disease state including non-alcoholic fatty liver disease (NAFLD) is a problem encountered even after the cure of hepatitis C. Moreover, there is currently no reliable in vitro model capable of investigating host-viral interactions and monitoring the progression of viral hepatitis to chronic liver diseases. Recent organoid technology has been reported for successful infection of HCV, but there is still lack of non-parenchymal cells, which play a crucial role in disease progression. Here, we provided a novel multicellular liver organoid model using co-culture system of macrophages and liver organoids differentiated from the same cell source, human embryonic stem cells. Surprisingly, HCV infection led potent lipid accumulation in liver organoids through regulation of host lipid metabolism, which was further promoted by macrophage co-culture. Lipid enriched condition provided by longterm-treatment with fatty acid accelerated potent HCV amplification and further promotion of inflammation and fibrosis progression. Therefore, our model may be a valuable novel platform recapitulating diverse phenotypes with host-virus intercommunication and inter-cellular interactions and further progressive features of hepatitis C-associated chronic NAFLD progression of patients with HCV.

2024-05-05 | GSE229608 | GEO

Multicellular liver organoid model for recapitulating hepatitis C virus infection and non-alcoholic fatty liver disease progression [RNA-Seq]

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Multicellular liver organoid model for recapitulating hepatitis C virus infection and non-alcoholic fatty liver disease progression

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Multicellular liver organoid model for recapitulating hepatitis C virus infection and non-alcoholic fatty liver disease progression [RNA-Seq]

Project description:Multicellular liver organoid model for recapitulating hepatitis C virus infection and non-alcoholic fatty liver disease progression [RNA-Seq]

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INTEAM CONSORTIUM - ALCOHOLIC HEPATITIS LIVER RNA SEQUENCING

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INTEAM CONSORTIUM - ALCOHOLIC HEPATITIS LIVER RNA SEQUENCING

Project description:INTEAM CONSORTIUM - ALCOHOLIC HEPATITIS LIVER RNA SEQUENCING

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Multicellular liver organoid model for recapitulating hepatitis C virus infection and non-alcoholic fatty liver disease progression

Project description:This SuperSeries is composed of the SubSeries listed below.

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Intrahepatic lipocalin 2 promotes liver fibrosis in alcoholic hepatitis

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Expression data from human non-alcoholic fatty liver disease stages

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