Ontology highlight
ABSTRACT:
PROVIDER: PRJNA956977 | ENA |
REPOSITORIES: ENA
Similar Datasets
Project description:ddRAD sequence data of Jacobaea vulgaris (Asteraceae)
| PRJEB56266 | ENA
Project description:In flowers of Asteraceae, yellow flavonols bearing an additional hydroxyl group at positions 6 or 8 (ring A) contribute to petal UV-absorbing pigmentation patterns, which play a crucial role in attracting pollinating insects. Understanding the biogenesis of these special flavonols requires the identification of any specific enzyme involved in these incorporations of extra hydroxyl groups on the quercetin ring A. To this aim, flavonol-bearing biotinylated probes have been designed and synthesized to explore their ability to selectively capture target proteins or biosynthetic enzymes under oxidative activation. These probes demonstrate the ability to capture several flavonoid enzymes from Rudbeckia and Tagetes microsomes and allow the identification of uncharacterized candidates for novel flavonoid enzymes.
2023-07-20 | PXD041520 | Pride
Project description:Interventions: Individual who are the first in their family to undertake mutation detection for a pathogenic mutation in either breast, ovarian or colorectal cancer and test positive are designated the proband. Probands are randomised to inform first and second degree relatives of their potential risk via either an active or passive method of disclosure. On the active disclosure arm, probands are encouraged to communicate directly with their relatives to inform them of their potential risk. In addition a Risk Notification Letter will be sent by the Familial Cancer Centre (FCC) to at risk relatives (ARR) informing them of the same. Probands randomised to the passive arm will be encouraged to inform their relatives of their potential risk but the FCC will not make contact with ARRs. Expected duration of recruitment and data capture phase of trial is 24 months.
Primary outcome(s): The number of at-risk relatives who contact the FCC for further information[One year after randomisation]
Study Design: Purpose: Educational / counselling / training; Allocation: Randomised controlled trial; Masking: Open (masking not used);Assignment: Parallel;Type of endpoint: Safety/efficacy
| 2453394 | ecrin-mdr-crc