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RNAseq identifies differentially expressed genes upon SON overexpression in WT and Mettl3 cKO LSK cells

ABSTRACT: RNAseq identifies differentially expressed genes upon SON overexpression in WT and Mettl3 cKO LSK cells

PROVIDER: PRJNA967215 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR24425500_1.fastq.gz	Fastqsanger.gz
	SRR24425500_2.fastq.gz	Fastqsanger.gz
	SRR24425501_1.fastq.gz	Fastqsanger.gz
	SRR24425501_2.fastq.gz	Fastqsanger.gz
	SRR24425502_1.fastq.gz	Fastqsanger.gz

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RNAseq identifies differentially expressed genes upon SON overexpression in WT and Mettl3 cKO LSK cells

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single cell RNAseq identifies differential expressed genes upon SON overexpression in WT and Mettl3 cKO LSK cells

Project description:The goal of this study is to identify gene expression changes upon SON overexpression in WT and Mettl3 cKO LSK (Lin-cKit+Sca1+) cells at single cell level

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single cell RNAseq identifies differential expressed genes upon SON overexpression in WT and Mettl3 cKO LSK cells

Project description:single cell RNAseq identifies differential expressed genes upon SON overexpression in WT and Mettl3 cKO LSK cells

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mRNA-Seq of mouse Mettl3 cKO and Fto cKO hippocampus after fear conditioning

Project description:N6-Methyladenosine (m6A) and N6,2′-O-dimethyladenosine (m6Am) are abundant mRNA modifications that regulate transcript processing and translation. The role of both, here termed m6A/m, in the stress response in the adult brain in vivo are currently unknown. Here, we investigated the effect of gene deletion of Mettl3, a m6A methyltransferase, and Fto, a m6A and m6Am demethlyase, induced in adulthood in excitatory neurons of the CA1 and CA3 in the hippocampus (Nex-CreERT2 Mettl3 or Fto cKO) on the transcriptome of CA1 and CA3 as well as the transcriptomic response of the CA1 and CA3 transcriptome to fear conditioning.

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m6A/m-Seq of mouse adult cortex of Mettl3 cKO or Fto cKO mice

Project description:N6-Methyladenosine (m6A) and N6,2′-O-dimethyladenosine (m6Am) are abundant mRNA modifications that regulate transcript processing and translation. The role of both, here termed m6A/m, in the stress response in the adult brain in vivo are currently unknown. Here, we investigated the effect of gene deletion of Mettl3, a m6A methyltransferase, and Fto, a m6A and m6Am demethlyase, induced in adulthood in excitatory neurons of the neocortex and hippocampus (Camk2a-Cre Mettl3 or Fto cKO) on the cortical epitranscriptome. PolyA-RNA-fragments from 3-5 replicates per group were processed both as m6A/m-sample (RNA immunoprecipiation RIP with an m6A and m6Am antibody) and RNA-input sample.

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mRNA-Seq of mouse Mettl3 cKO and Fto cKO hippocampus after fear conditioning

Project description:mRNA-Seq of mouse Mettl3 cKO and Fto cKO hippocampus after fear conditioning

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Transcription profiling of PVN/SON region of mouse brain after saline treatment to identify differentially expressed miRNAs

Project description:Identifying of differentially expressed miRNAs in PVN/SON region of the brain after saline treatment.

2006-10-02 | E-MEXP-786 | biostudies-arrayexpress

Differentially expressed genes in Mettl3-deficient livers compared to control livers

Project description:Liver-specific deficiency of Mettl3 causes liver injury. By performing RNA sequencing (RNA-seq) analysis on the Mettl3-deficient versus control livers, we identified the potential target genes that were closely associated with the liver phenotype in liver-specific Mettl3 knockout mice. RNA-seq analysis revealed extensive metabolic reprogramming in Mettl3-deficient livers. These results demonstrated that Mettl3 coordinates metabolic homeostasis and functional maturation during postnatal liver development.

2022-03-09 | GSE197800 | GEO

m6A/m-Seq of mouse adult cortex of Mettl3 cKO or Fto cKO mice

Project description:m6A/m-Seq of mouse adult cortex of Mettl3 cKO or Fto cKO mice

| PRJNA454049 | ENA

Genes differentially expressed in MLL-AF9-transduced versus HOXA9/MEIS1-transduced LSK cells

Project description:HOXA9 and MEIS1 are essential downstream effectors of the MLL-AF9 oncoprotein during leukaemia induction. Leukaemia derived from MLL-AF9-transduced LSK cells has a more aggressive phenotype than that derived from HOXA9/MEIS1-transduced LSK cells. To determine differential gene expression that contributes to increased aggressiveness in MLL-AF9-induced leukaemia, microarray was performed on LSK cells transduced with MLL-AF9 versus HOXA/MEIS1 oncogenes.

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