Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Single-nucleus RNA-seq of healthy (sham) and heart diseased (TAC) SCGs

ABSTRACT: single-nucleus RNA-seq of healthy (sham) and heart diseased (TAC) SCGs

PROVIDER: PRJNA967655 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR24445645_1.fastq.gz	Fastqsanger.gz
	SRR24445645_2.fastq.gz	Fastqsanger.gz
	SRR24445646_1.fastq.gz	Fastqsanger.gz
	SRR24445646_2.fastq.gz	Fastqsanger.gz

Items per page:

1 - 4 of 4

Similar Datasets

single-cell RNA-seq of healthy (ctrl) and heart diseased (TAC) SCGs

Project description:single-cell RNA-seq of healthy (ctrl) and heart diseased (TAC) SCGs

| PRJNA967656 | ENA

heart healthy and heart diseased SCGs

Project description:heart healthy and heart diseased SCGs

| PRJNA967648 | ENA

single-nucleus RNA-seq of healthy (sham) and heart diseased (TAC) SCGs

Project description:Disruption of the physiologic sleep-wake cycle and low melatonin levels frequently accompany cardiac disease, yet the underlying mechanism has remained enigmatic. Immunostaining of sympathetic axons in optically cleared pineal glands from humans and mice with cardiac disease revealed their substantial denervation compared to controls. Spatial, single-cell, nuclear, and bulk RNA sequencing traced this defect back to the superior cervical ganglia (SCG), which responded to cardiac disease with accumulation of inflammatory macrophages, fibrosis, and the selective loss of pineal gland-innervating neurons. Depletion of macrophages in the SCG prevented disease-associated denervation of the pineal gland and restored physiological melatonin secretion. Our data identify the mechanism underlying the disturbance of diurnal rhythmicity in cardiac disease and suggest means for therapeutic intervention.

2023-07-20 | GSE231765 | GEO

RNA-seq of heart healthy and heart diseased SCGs

Project description:RNA-seq of heart healthy and heart diseased SCGs

| PRJNA967653 | ENA

RNA-seq of heart healthy and heart diseased SCGs and pineal glands

Project description:RNA-seq of heart healthy and heart diseased SCGs and pineal glands

| PRJNA967654 | ENA

RNA-sequencing of wild type and Piezo1-Cko mice under sham or TAC surgery

Project description:Mechanotransduction has been lately recognized as a major regulator of organ homeostasis under a myriad of pathological conditions. The role of Piezo1 in cardiac hypertrophy has never been explored. Here we performed RNA-Seq assay for wild type and Piezo1-Cko mice under sham or TAC surgery.

2024-01-01 | GSE179107 | GEO

mRNA profiling after TAC/Sham surgery in NRON KO/wt mice

Project description:mRNA profiling after TAC/Sham surgery in NRON KO/wt mice

| PRJNA780194 | ENA

Genome-wide analysis of the effect of TUDCA on 1 week transveres aortic constriction (TAC) mouse

Project description:The hypothesis tested in the present study was that ameliorating ER stress by TUDCA could reduce the cardiac remodeling in TAC mice. Results provide important information of the genes that were up- or down-regulated in Veh-TAC operated animals in comparison to Sham, TUDCA -Sham and TUDCA-TAC mice.

2017-04-12 | GSE89539 | GEO

Transcription profiling of left ventricular myocardium after sham or TAC surgery in BL/6N and BL/6J mice

Project description:The most commonly used inbred mouse strain, C57BL/6J, lacks a functional nicotinamide nucleotide transhydrogenase (Nnt) and thus, is protected from pressure-overload-induced oxidative stress and heart failure. We screened for differential gene expression in left ventricular myocardium after sham/transverse aortic constriction (TAC) surgery in 10-12 weeks old mice from BL/6N (functional Nnt) and BL/6J (non-functional Nnt, missense of exons 7-11) strains.

2015-06-21 | E-MTAB-2732 | biostudies-arrayexpress

Candidatus Phytoplasma sacchari strain:SCGS

Project description:Sugarcane Grassy Shoot (SCGS) phytoplasma strain SCGS

| PRJNA565134 | ENA