Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Effect of ATRX deficiency on gene expression of RCAS-nTva derived murine gliomas [RNA-seq: ATRX_Immuno_cell_line]

ABSTRACT: Effect of ATRX deficiency on gene expression of RCAS-nTva derived murine gliomas [RNA-seq: ATRX_Immuno_cell_line]

PROVIDER: PRJNA967995 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR24457636_1.fastq.gz	Fastqsanger.gz
	SRR24457636_2.fastq.gz	Fastqsanger.gz
	SRR24457637_1.fastq.gz	Fastqsanger.gz
	SRR24457637_2.fastq.gz	Fastqsanger.gz
	SRR24457638_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 12

Similar Datasets

Effect of ATRX deficiency on gene expression of RCAS-nTva derived murine gliomas

Project description:Effect of ATRX deficiency on gene expression of RCAS-nTva derived murine gliomas

| PRJNA967990 | ENA

Effect of ATRX deficiency on gene expression of RCAS-nTva derived murine gliomas [RNA-seq: ATRX_Immuno_Tumor]

Project description:To investigate the impact of ATRX loss on tumor microenvironment we generated ATRX-intact and -deficient tumors in immune competent mice with the RCA-nTva system. Mice were injected with a tumorigenic RCAS construct (PDGFa and shTP53) and an RCAS bearing CRE recombinase. This was performed in mice that were ATRX wt and ATRX floxed.

2023-05-08 | GSE231831 | GEO

Effect of ATRX deficiency on gene expression of RCAS-nTva derived murine gliomas [RNA-seq: ATRX_Immuno_cell_line]

2023-05-08 | GSE231830 | GEO

Effect of ATRX deficiency on gene expression of RCAS-nTva derived murine gliomas [RNA-seq: ATRX_Immuno_Tumor]

Project description:Effect of ATRX deficiency on gene expression of RCAS-nTva derived murine gliomas [RNA-seq: ATRX_Immuno_Tumor]

| PRJNA967996 | ENA

Epigenomic analysis of Atrx deficiency in murine glioma cells of orgin [Atrx ChIP]

Project description:The chromatin regulator ATRX is inactivated in large subsets of adult and pediatric glioma. Whether and how ATRX deficiency promotes oncogenesis by epigenomic dysregulation remains unclear. We found that Atrx loss, especially when coupled with Tp53 inactivation, promoted cell motility and modulated differentiation state in primary murine neuroepithelial progenitors, recapitulating characteristic disease phenotypes and molecular features. Moreover, Atrx deficiency induced widespread shifts in chromatin accessibility, histone composition, and gene transcription at vacant Atrx binding sites distributed across the genome. Finally, target genes mediating Atrx-deficient phenotypes in vitro exhibited similarly selective misexpression in ATRX-mutant human glioma tissues and cell lines. These findings demonstrate that, in appropriate physiological contexts, ATRX deficiency and its epigenomic sequelae are sufficient to induce disease-defining oncogenic phenotypes.

2017-12-31 | GSE100462 | GEO

RNAseq analysis of murine brainstem gliomas with and without H3.3K27M

Project description:Using the RCAS/tv-a system, we induced murine brainstem gliomas (PDGF-B; p53 loss using RCAS-Cre with and without H3.3K27M) in Nestin tv-a; p53 floxed mice

2017-05-11 | GSE98765 | GEO

Epigenomic analysis of Atrx deficiency in murine glioma cells of orgin [RNA-seq]

2017-12-31 | GSE100464 | GEO

Epigenomic analysis of Atrx deficiency in murine glioma cells of orgin [H3.3 ChIP]

2017-12-31 | GSE100463 | GEO

Epigenomic analysis of Atrx deficiency in murine glioma cells of orgin [ATAC-seq]

2017-12-31 | GSE100461 | GEO

Epigenomic analysis of Atrx deficiency in murine glioma cells of orgin

Project description:Epigenomic analysis of Atrx deficiency in murine glioma cells of orgin

| PRJNA391898 | ENA