Ajuga reptans
Ontology highlight
ABSTRACT:
PROVIDER: PRJNA970766 | ENA |
REPOSITORIES: ENA
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| Other | ||||
| SRR24502601_1.fastq.gz | Fastqsanger.gz | |||
| SRR24502601_2.fastq.gz | Fastqsanger.gz |
Items per page: 5 1 - 3 of 3 |
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Project description:Transcriptomes of endangered plants in oceanic Islands (Ajuga)
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Project description:Ajuga reptans (bugle), genomic and transcriptomic data
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Project description:<p>Several herbivorous insects consume certain metabolites from plants for other purposes than nutrition, such as defence. Adults of the turnip sawfly, <em>Athalia rosae</em> take up specific terpenoids, called clerodanoids, from <em>Ajuga reptans</em>. These metabolites are slightly modified by the sawflies and influence their mating behaviour and defence against predators. We characterised these metabolites and investigated their localisation in the insect and the specificity of the uptake and metabolite modification. Therefore, we performed feeding assays with adults and larvae of <em>A. rosae</em> as well as larvae of <em>Spodoptera exigua</em>, followed by chemical analyses. Two main clerodanoid-derived metabolites were detected in the abdomen and thorax but also on the surface of the adults. Small amounts were also found in larvae of the sawfly, while they were not detectable in <em>S. exigua</em>. Our findings provide new insights into the peculiarities of pharmacophagy and specialised metabolism in <em>A. rosae</em>.</p>
2023-10-30 | MTBLS7508 | MetaboLights
Project description:Hepatitis C is a serious health issue and cause liver disorders in millions of people. Available therapeutic agents require long term administration with numerous side effects. Therefore, there is a dire need to find alternative treatment options for this disease. Since ancient times, medicinal plants are widely used to cure various diseases with no or less harmful effects. Therefore, this study was designed to find out phytochemicals and investigate antiviral activity of methanol extract of Ajuga bracteosa, Ajuga parviflora, Berberis lycium and Citrus lemon against Hepatitis C Virus (HCV infection). Phytochemical analysis of the plant extract was performed using various chemical tests. Toxicity of the plant extract was determined against using trypan blue exclusion method. Antiviral activity of the selected plant extract was find out against HCV infected HepG2 cells. For this purpose, HepG2 cells were seeded with HCV positive and negative serum and nontoxic doses of plant extract for 24 and 48 h. After this RNA was extracted and viral load was determined using Real-time PCR. Phytochemical analysis showed the presence of flavonoids and phenols in all plant extracts while amino acids, alkaloids and tannins were present in B. lycium and saponins were detected in C. lemon. Toxicity assay showed that all plant extracts were nontoxic at maximum concentration of 200 μg/ml except B. lycium, which showed mild toxicity at 40 μg/ml and were extremely toxic at 60 μg/ml and above doses. Real-time PCR quantitation result revealed that after 24 h treatments A. parviflora showed highest antiviral activity, followed by A. bracteosa, while B. lycium extract had low (35%) and C. lemon has no antiviral effects. The 48 h treatments showed an increase antiviral activity by A. bracteosa followed by A. parviflora and B. lycium while C. lemon showed negative effect. Our results depicted that mentioned plants might be used as an alternative therapeutic regime or in combination with existing treatments against HCV.
| S-EPMC7127416 | biostudies-literature