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Effect of TRIB1 knockdown on gene expression in MCF7 breast cancer cells

ABSTRACT: Effect of TRIB1 knockdown on gene expression in MCF7 breast cancer cells

PROVIDER: PRJNA975104 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR24685548.fastq.gz	Fastqsanger.gz
	SRR24685549.fastq.gz	Fastqsanger.gz
	SRR24685550.fastq.gz	Fastqsanger.gz
	SRR24685551.fastq.gz	Fastqsanger.gz
	SRR24685552.fastq.gz	Fastqsanger.gz

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Effect of TRIB1 knockdown on gene expression in MCF7 breast cancer cells

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Project description:Gene expression analysis of MEL-18-silenced MCF7 cell lines. MEL-18 is a component of the polycomb repressive complex (PRC)-1, which is a critical epigenetic modulator of stem cell regulation and normal and cancerous development. Accumulating studies have suggested that MEL-18 might act as a tumor suppressor in several human tumors, including breast cancer. Results provide insight into the functional role of MEL-18 in estrogen-dependent breast cancer. MCF7 cells stably infected with lentiviruses encoding either control (shCon) or MEL-18 shRNA (shMEL) were cultured in phenol-red free DMEM supplemented with 10% FBS for 48 h. Total RNA was isolated from the cultures using Trizol reagent. For each of the 2 conditions, 2 biological replicates were included. In total, 4 microarray samples were analyzed; 2 controls and 2 shRNA MEL-18 knockdowns. All labeling, hybridization and scanning steps were performed according to the manufacturers’ instructions.

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