Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Structured wound angiogenesis instructs mesenchymal barrier compartments in the regenerating nerve [scRNASeq_Cdh5]

ABSTRACT: Structured wound angiogenesis instructs mesenchymal barrier compartments in the regenerating nerve [scRNASeq_Cdh5]

PROVIDER: PRJNA976059 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR24727851_1.fastq.gz	Fastqsanger.gz
	SRR24727851_2.fastq.gz	Fastqsanger.gz
	SRR24727852_1.fastq.gz	Fastqsanger.gz
	SRR24727852_2.fastq.gz	Fastqsanger.gz
	SRR24727853_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 8

Similar Datasets

Structured wound angiogenesis instructs mesenchymal barrier compartments in the regenerating nerve

Project description:Structured wound angiogenesis instructs mesenchymal barrier compartments in the regenerating nerve

| PRJNA975918 | ENA

Structured wound angiogenesis instructs mesenchymal barrier compartments in the regenerating nerve [bulkRNASeq]

Project description:Structured wound angiogenesis instructs mesenchymal barrier compartments in the regenerating nerve [bulkRNASeq]

| PRJNA976056 | ENA

Structured wound angiogenesis instructs mesenchymal barrier compartments in the regenerating nerve [scRNASeq_Pdgfrb]

Project description:Structured wound angiogenesis instructs mesenchymal barrier compartments in the regenerating nerve [scRNASeq_Pdgfrb]

| PRJNA976057 | ENA

Structured wound angiogenesis instructs mesenchymal barrier compartments in the regenerating nerve [bulkRNASeq]

Project description:Organ injury stimulates the formation of new capillaries to restore blood supply raising questions about the potential contribution of neoangiogenic vessel architecture to the healing process. With single-cell mapping we resolved the properties of endothelial cells that organize a polarized scaffold at the repair site of lesioned peripheral nerves. Transient reactivation of an embryonic guidance program is required to orient neovessels across the wound. Manipulation of this structured angiogenic response through genetic and pharmacological targeting of Plexin-D1/VEGF pathways within an early window of repair has long-term impact on configuration of the nerve stroma. Neovessels direct nerve-resident mesenchymal cells to mold a provisionary fibrotic scar by assembling an orderly system of stable barrier compartments that channel regenerating nerve fibers and shield them from the persistently leaky vasculature. Thus, guided and balanced repair angiogenesis enables the construction of a “bridge” microenvironment conducive for axon regrowth and homeostasis of the regenerated tissue.

2023-11-21 | GSE233355 | GEO

Structured wound angiogenesis instructs mesenchymal barrier compartments in the regenerating nerve [scRNASeq_Pdgfrb]

2023-11-21 | GSE233359 | GEO

Structured wound angiogenesis instructs mesenchymal barrier compartments in the regenerating nerve [scRNASeq_Cdh5]

2023-11-21 | GSE233357 | GEO

Structured wound angiogenesis instructs mesenchymal barrier compartments in the regenerating nerve

Project description:This SuperSeries is composed of the SubSeries listed below.

2023-11-21 | GSE233360 | GEO

Blood flow diverts extracellular vesicles from endothelial degradative compartments to promote angiogenesis

Project description:Blood flow diverts extracellular vesicles from endothelial degradative compartments to promote angiogenesis

| PRJEB64225 | ENA

Regenerating axolotl retinas regrow diverse cell types with modulation by Notch signaling and reconnect to the brain

Project description:We examined uninjured and regenerating axolotl salamander retinas, including their transcriptional profile. We report that at 27 days after a retinectomy (early-mid regeneration), regenerating axolotl retinas exhibit downregulation of genes associated with neuronal networks but upregulation of genes associated with angiogenesis and the extracellular matrix. We also report differential expression of two Notch pathway effector genes, Hes1 and Hes5.

2022-04-10 | GSE200423 | GEO

Regenerating Zebrafish fins: Controls vs. regenerating fins (3 days following fin amputation)

Project description:Transcriptional profiling of zebrafish rergenerating fins comparing control fins and regenerating fins (3 days following fin amputation)

2017-02-09 | GSE58567 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data