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ScRNA-seq analysis of SHH medulloblastomas in Gfap-Cre/SmoM2 mice treated with CT-179 or Pox-resiquimod

ABSTRACT: scRNA-seq analysis of SHH medulloblastomas in Gfap-Cre/SmoM2 mice treated with CT-179 or Pox-resiquimod

PROVIDER: PRJNA976492 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR24743389_1.fastq.gz	Fastqsanger.gz
	SRR24743389_2.fastq.gz	Fastqsanger.gz
	SRR24743390_1.fastq.gz	Fastqsanger.gz
	SRR24743390_2.fastq.gz	Fastqsanger.gz
	SRR24743391_1.fastq.gz	Fastqsanger.gz

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scRNA-seq analysis of SHH medulloblastomas in Gfap-Cre/SmoM2 mice treated with CT-179 or Pox-resiquimod

Project description:Our parallel studies have shown that the OLIG2 inhibitor CT-179 and the TLR7/8 agonist resiquimod delivered in polyoxazoline nanoparticle (Pox-resiquimod) produce significant anti tumor effects when administered to mice with SHH medulloblastoma. To gain insight into the cellular events set in motion by each treatment, we compared sets of replicate mice with SHH medulloblastomas treated with either CT-179 or POx-resiquimod to a common set of untreated control mice with SHH medulloblastoma.

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