Project description:To investigate the immune function of SEPT2 in the regulation of viral infection, we obtained SEPT2-deficient PMs from SEPT2 conditional knockout mice. We then performed gene expression profiling analysis using data obtained from RNA-seq of wild-type and SEPT2-deficient PMs with VSV or HSV-1 infection.

2022-09-23 | GSE213863 | GEO

Enrichment of sgRNA in a genome-wide CRISPR-cas9 knockout screening assay in HSV-1 infected the human amnionic WISH cells models.

Project description:The Human CRISPR Knockout Pooled Library (GeCKO v2, 1000000048, Addgene) was transferred into WISH cells. Then,half of these cells were infected with HSV-1 for 30 hours, and the remaining lived infected cells and uninfected cells were collected for sgRNA sequencing and enrichment analysis.

2024-06-01 | GSE223085 | GEO

Transcription profiling of HSV-1 infected murine embryonic stem cells

Project description:Transcription profiling of HSV-1 infected murine embryonic stem cells

2012-01-02 | E-MTAB-882 | biostudies-arrayexpress

LC-MSMS of HSV-1 infected HFFs

Project description:Herpes simplex virus 1 (HSV-1) is the causative agent of the common cold sores and life-threatening disease. Here, we characterize the full complement of viral gene expression during lytic infection using an integrative Omics approach. This revealed hundreds of novel viral gene products arising from differential usage of transcription and translation start sites. We classify these into viral gene modules and provide a comprehensive state-of-the-art annotation of all HSV-1 gene products.

2020-05-22 | PXD013010 | Pride

Expression data comparing 8024 wild type (WT) and MAEL knockout (KO) cells

Project description:To identify candidate genes regulated cancer stemness property of HCC by comparing 8024 wild type (WT) and MAEL knockout (KO) cells, which applied by RNA-Sequencing.

2021-05-25 | GSE175454 | GEO

RNAseq comparison of HSV-1 KOS vs n199 infected cells

Project description:The abundance of HSV mRNAs was determines over 16h of infection in wt (KOS) and n199 (ICP22 mutant) infected cells. ICP22 is an immediate early gene of HSV that affects gene expression

2018-01-20 | GSE109420 | GEO

Gene expression in RAW264.7 cells infected with VSV and HSV-1

Project description:The purpose of this study was to determine which genes are differentially regulated virus infection in RAW264.7 cells. Cells were infected with Vesicular Stomatitis Virus (VSV) or herpes simplex virus 1 (HSV-1) for 6h. Then the differentially regulated genes were analyzed, focusing on F-box proteins and E3 ubiquitin ligases. RAW264.7 cells were infected with Vesicular Stomatitis Virus (VSV, MOI=1) or herpes simplex virus 1 (HSV-1, MOI=5) for 6h. Equal amounts of RNA were assayed for gene expression using Affymetrix mouse 430 2.0 arrays.

2016-04-05 | E-GEOD-72077 | biostudies-arrayexpress

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