Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Effects of morphine exposure on the transcriptome of the dorsalmedial prefrontal cortex (dmPFC) in rats

ABSTRACT: Effects of morphine exposure on the transcriptome of the dorsalmedial prefrontal cortex (dmPFC) in rats

PROVIDER: PRJNA978587 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR24796000_1.fastq.gz	Fastqsanger.gz
	SRR24796000_2.fastq.gz	Fastqsanger.gz
	SRR24796001_1.fastq.gz	Fastqsanger.gz
	SRR24796001_2.fastq.gz	Fastqsanger.gz
	SRR24796002_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 24

Similar Datasets

Perinatal morphine exposure and the offspring prefrontal cortex

Project description:To investigate how exposure to morphine during the prenatal and early postnatal period affects the offspring prefrontal cortex in a mouse model We performed gene expression profiling analysis using data obtained from RNA-seq of offspring prefrontal cortical brain samples at postnatal day 21

2022-10-26 | GSE206032 | GEO

Perinatal morphine exposure and the offspring prefrontal cortex

Project description:Perinatal morphine exposure and the offspring prefrontal cortex

| PRJNA848819 | ENA

Effects of morphine exposure on the transcriptome of the dorsalmedial prefrontal cortex (dmPFC) in rats

Project description:We investigated changes in gene transcription induced by subcutanuous morphine injection in adult male and female rats' dmPFC.

2023-06-06 | GSE233922 | GEO

Comparative phosphoproteomic profiling in prefrontal cortex of prenatal stressed offspring rats

Project description:We used MS-based TMT quantitative proteomics in combination with phosphopeptide enrichment method to compare phosphoproteomic profiling in prefrontal cortex of of PS-S and CON offspring rats.

2022-08-12 | PXD026563 | Pride

MicroRNA expression profiling of prefrontal cortex samples from C57 mice treated with saline or morphine

Project description:Our previous study showed that Dicer1 expression is positively correlated with the development of analgesic tolerance. To further understand the miRNA regulation by Dicer in the development of tolerance, we performed microRNA profiling using Agilent mouse miRNA arrays to identify the miRNA profiles in the prefrontal cortex from C57BL/6J (C57) mice under saline or morphine treatment.

2016-11-01 | GSE75893 | GEO

Transcriptional analysis of neonatal mouse cortex following morphine exposure

Project description:Transcriptional analysis of neonatal mouse cortex following morphine exposure

| PRJNA935756 | ENA

Gene expression change in the cerebellum and prefrontal cortex of depression rats

Project description:The depressive-like behavior in animals is usually assessed by standardized behavioral tests such as the forced swimming test. However, the findings of these tests may be affected by individual variability among animals, which may hinder the discovery of genes responsible for depression. Few reports have showed the influence of individual variability in identifying the genes associated with depressive-like behavior. In this study, we measured the immobility ratio (% immobility in 5 min) in the forced swimming test in 106 male Wistar rats. According to the distribution of individual immobility ratio, the rats were divided into three groups: the control group with immobility ratio -1 to +1 standard deviation (SD) from the mean, the depressive group with immobility ratio +1 to +2 SD above the mean, and the anti-depressive group with immobility ratio -1 to -2 SD below the mean. Microarray analysis was used to identify the genes differentially expressed by depressive group rats in the prefrontal cortex and cerebellum. The differentially expressed genes in both brain regions of the depressive group were Alas2, Gh1, Hba-a2, Hbb, Hbb-b1, Hbe2, LOC689064, Mrps10, Mybpc, Olf6415, and Pfkb1. Ingenuity pathway analysis identified Gh1 as a hub gene in the networks of the differentially expressed genes in both brain regions. This study indicates that inherent differences in depressive-like behavior may be related to the Gh1 expression in the cerebellum and prefrontal cortex. We measured the immobility ratio of 106 normal rats using the forced swimming test and statistically analysis. We selected the rats exhibitting depressive-like behavior or average in the 106 rats. Total RNA was prepareted from the cerebellum and prefrontal cortex. An equal amount of RNA from 4 rats in each group was pooled and used for microarray analysis.

2015-02-26 | E-GEOD-63377 | biostudies-arrayexpress

Transcriptomic analysis of prefrontal medial cortex, hippocampus and nucleus accumbens of alcohol-preferring and nonpreferring rats

Project description:Animal models provide opportunity to study neurobiological aspects of human alcoholism. Changes in gene expression have been implicated in mediating brain function, including reward system and addiction. The current study aimed to identify novel genes that may underlie ethanol preference. Microarray analysis comparing gene expression in nucleus accumbens (NAc), hippocampus (HP) and prefrontal medial cortex (mPFC) was performed in two rat strains selected for extreme levels of ethanol preference - Warsaw High Preferring (WHP) and Warsaw Low Preferring (WLP). The identified candidate genes may underlie differential ethanol preference in rat model of alcoholism. This is analysis of 18 RNA samples, including 9 technical replicates. Two strains of rats selected for extreme levels of ethanol preference (low preferring WLP and high preferring WHP) were compared. Three brain areas (nucleus accumbens, prefrontal medial cortex and hippocampus) were studied. For each brain area, 6 RNA samples (including 3 technical replicates) were analyzed. Each RNA sample consist of of equal amounts of total RNA from 3 male rats. Comparisons: Nucleus accumbens of WHP vs. Nucleus accumbens of WLP; Prefrontal medial cortex of WHP vs. Prefrontal medial cortex of WLP; Hippocampus of WHP vs. Hippocampus of WLP. 3 biological replicates in each comparison.

2015-01-17 | E-GEOD-65064 | biostudies-arrayexpress

Transcriptional analysis of neonatal mouse cortex following morphine exposure

Project description:We developed a mouse model of NOWS that includes gestational and post-natal morphine exposure that encompasses the developmental equivalent of all three human trimesters of gestation. This exposure paradigm causes delayed developmental milestones and acute withdrawal phenotypes reminiscent of those observed in infants.

2023-12-15 | GSE225468 | GEO

Impact of cognitive performance and normal aging on transcriptomic changes in the prefrontal cortex of rats

Project description:We investigated how cognitive stimulation impacts gene expression in the prefrontal cortex (PFC), a brain region known to regulate higher cognitive functions including the control of attention, in young and aged rats.

2019-10-20 | GSE105453 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data