Proteomics

Dataset Information

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Comparative phosphoproteomic profiling in prefrontal cortex of prenatal stressed offspring rats


ABSTRACT: We used MS-based TMT quantitative proteomics in combination with phosphopeptide enrichment method to compare phosphoproteomic profiling in prefrontal cortex of of PS-S and CON offspring rats.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Rattus Norvegicus (rat)

TISSUE(S): Prefrontal Cortex

DISEASE(S): Abnormality Of Prenatal Development Or Birth

SUBMITTER: Wei He  

LAB HEAD: Hongli Sun

PROVIDER: PXD026563 | Pride | 2022-08-12

REPOSITORIES: Pride

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Publications

Comparative Phosphoproteomic Profiling in the Prefrontal Cortex of Prenatally Stressed Male Offspring Rats.

He Wei W   Huang Huimei H   Zhang Huiping H   Sun Hongli H  

Developmental neuroscience 20220714 6


Many investigations have indicated that prenatal stress (PS) causes depressive-like disturbances in offspring rats. However, the underlying pathogenic mechanisms have not yet been fully elucidated. The prefrontal cortex (PFC) has been shown to play a role in susceptibility to stress during fetal development; thus, we focused our attention on differential protein phosphorylation in this region of PS-S (susceptibility to PS) offspring rats. The sucrose preference test was used to screen for suscep  ...[more]

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