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Transcriptomic analysis in brown adipose tissue from the brown adipocytes-specific Crif1 deficiency mice

ABSTRACT: Transcriptomic analysis in brown adipose tissue from the brown adipocytes-specific Crif1 deficiency mice

PROVIDER: PRJNA978721 | ENA |

REPOSITORIES: ENA

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Transcriptomic analysis in brown adipose tissue from the brown adipocytes-specific Crif1 deficiency mice

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Comparative secretome analysis of primary murine white and brown adipocytes

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2018-09-04 | PXD009280 | Pride

Analysis of gene expression patterns in brown adipose tissue

Project description:Brown adipose tissue is a specialized fat tissue involved in heat generation by using a process termed thermogenesis. This ability to convert nutrient energy into heat sets brown adipocytes apart from the more common type of white adipocytes, which are mainly involved in energy storage. Brown adipose depots occur as a large interscapular depot in mice. Brown adipocytes are multilocular, i.e. contain many small lipid-filled vacuoles and uniquely express the uncoupling protein 1. In this study, the gene expression patterns in brown adipose tissue samples of young, healthy mice was analyzed.

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Project description:Obesity and its co-morbidities including type 2 diabetes are increasing at epidemic rates in the U.S. and worldwide. Brown adipose tissue (BAT) is a potential therapeutic to combat obesity and type 2 diabetes. Increasing BAT mass by transplantation improves metabolic health in rodents, but its clinical translation remains a challenge. Here, we investigated if transplantation of 2-4 million differentiated brown pre-adipocytes from mouse BAT stromal fraction (SVF) or human pluripotent stem cells (hPSCs) could improve metabolic health. Transplantation of differentiated brown pre-adipocytes, termed ‘committed pre-adipocytes’ from BAT SVF from mice or derived from hPSCs improves glucose homeostasis and insulin sensitivity in recipient mice under conditions of diet-induced obesity, and this improvement is mediated through the collaborative actions of the liver transcriptome, tissue AKT signaling and FGF21. These data demonstrate that transplantation of a small number of brown adipocytes has significant long-term translational and therapeutic potential to improve glucose metabolism.

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Apoptotic brown adipocytes enhance energy expenditure via SLC29A1-regulated extracellular inosine

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Brown Adipose YY1 Deficiency Activates Expression of Secreted Proteins Linked to Energy Expenditure and Prevents Diet-Induced Obesity [BAT]

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