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The master male sex determinant Gdf6Y of the turquoise killifish arose through allelic neofunctionalization

ABSTRACT: The master male sex determinant Gdf6Y of the turquoise killifish arose through allelic neofunctionalization

PROVIDER: PRJNA979163 | ENA |

REPOSITORIES: ENA

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The master male sex determinant Gdf6Y of the turquoise killifish arose through allelic neofunctionalization [Human]

Project description:The master male sex determinant Gdf6Y of the turquoise killifish arose through allelic neofunctionalization [Human]

| PRJNA979165 | ENA

The master male sex determinant Gdf6Y of the turquoise killifish arose through allelic neofunctionalization [Mouse]

Project description:The master male sex determinant Gdf6Y of the turquoise killifish arose through allelic neofunctionalization [Mouse]

| PRJNA979170 | ENA

Circular RNAs in the ageing African turquoise killifish

Project description:In this work we took 9 samples from brain and 6 samples from muscle of the African turquoise killifish (Nothobranchius furzeri) at 3.5, 8.5 and 14 weeks. Total RNA was sequenced and circRNAs were detected.

2019-07-31 | GSE134065 | GEO

The master male sex determinant Gdf6Y of the turquoise killifish arose through allelic neofunctionalization [Mouse]

Project description:Although sex determination is a fundamental process in vertebrate development, it is very plastic. Diverse genes became major sex determinants in teleost fishes. Deciphering how individual sex-determining genes orchestrate sex determination can reveal new actors in sexual development. Here, we demonstrate that the Y-chromosomal copy of the TGF-β family member gdf6 (gdf6Y) in Nothobranchius furzeri, an emerging model organism in aging research, gained the function of the male sex determinant through allelic diversification while retaining the skeletal developmental function shared with the X-chromosomal gdf6 allele (gdf6X). Concerning sex determination, gdf6Y is expressed by somatic supporting cells of the developing testes. There it induces the male sex in a germ cell-independent manner in contrast to sex determination in zebrafish and the medaka. Looking for downstream effectors of Gdf6Y, we identified besides TGF-β signaling modulators, especially the inhibitor of DNA binding genes id1/2/3, the mRNA decay activator zfp36l2 as a new GDF6 signaling target.

2024-11-19 | GSE233995 | GEO

The master male sex determinant Gdf6Y of the turquoise killifish arose through allelic neofunctionalization [Human]

2024-11-19 | GSE233992 | GEO

Project description:The master male sex determinant Gdf6Y of the turquoise killifish arose through allelic neofunctionalization

| PRJNA974954 | ENA

The master male sex determinant Gdf6Y of the turquoise killifish arose through allelic neofunctionalization

Project description:This SuperSeries is composed of the SubSeries listed below.

2024-11-19 | GSE233997 | GEO

Circular RNAs in the ageing African turquoise killifish

Project description:Circular RNAs in the ageing African turquoise killifish

| PRJNA553674 | ENA

Chromosome conformation capture (Hi-C) of the turquoise killifish

Project description:Chromosome conformation capture (Hi-C) of the turquoise killifish

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Chromosome conformation capture (Hi-C) of the turquoise killifish

Project description:This approach was used to increase the continuity of the killifish genome, and assess the relative distance of specific genes from the sex locus.

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