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ABSTRACT: The master male sex determinant Gdf6Y of the turquoise killifish arose through allelic neofunctionalization

PROVIDER: PRJNA974954 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR24683242_1.fastq.gz	Fastqsanger.gz
	SRR24683242_2.fastq.gz	Fastqsanger.gz
	SRR24683244_1.fastq.gz	Fastqsanger.gz
	SRR24683244_2.fastq.gz	Fastqsanger.gz
	SRR24683247_1.fastq.gz	Fastqsanger.gz

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Similar Datasets

The master male sex determinant Gdf6Y of the turquoise killifish arose through allelic neofunctionalization

Project description:The master male sex determinant Gdf6Y of the turquoise killifish arose through allelic neofunctionalization

| PRJNA979163 | ENA

The master male sex determinant Gdf6Y of the turquoise killifish arose through allelic neofunctionalization [Human]

Project description:The master male sex determinant Gdf6Y of the turquoise killifish arose through allelic neofunctionalization [Human]

| PRJNA979165 | ENA

The master male sex determinant Gdf6Y of the turquoise killifish arose through allelic neofunctionalization [Mouse]

Project description:The master male sex determinant Gdf6Y of the turquoise killifish arose through allelic neofunctionalization [Mouse]

| PRJNA979170 | ENA

Project description:Whole genome sequencing of male African turquoise killifish

| PRJNA1121423 | ENA

The master male sex determinant Gdf6Y of the turquoise killifish arose through allelic neofunctionalization [Mouse]

Project description:Although sex determination is a fundamental process in vertebrate development, it is very plastic. Diverse genes became major sex determinants in teleost fishes. Deciphering how individual sex-determining genes orchestrate sex determination can reveal new actors in sexual development. Here, we demonstrate that the Y-chromosomal copy of the TGF-β family member gdf6 (gdf6Y) in Nothobranchius furzeri, an emerging model organism in aging research, gained the function of the male sex determinant through allelic diversification while retaining the skeletal developmental function shared with the X-chromosomal gdf6 allele (gdf6X). Concerning sex determination, gdf6Y is expressed by somatic supporting cells of the developing testes. There it induces the male sex in a germ cell-independent manner in contrast to sex determination in zebrafish and the medaka. Looking for downstream effectors of Gdf6Y, we identified besides TGF-β signaling modulators, especially the inhibitor of DNA binding genes id1/2/3, the mRNA decay activator zfp36l2 as a new GDF6 signaling target.

2024-11-19 | GSE233995 | GEO

The master male sex determinant Gdf6Y of the turquoise killifish arose through allelic neofunctionalization [Human]

2024-11-19 | GSE233992 | GEO

Circular RNAs in the ageing African turquoise killifish

Project description:In this work we took 9 samples from brain and 6 samples from muscle of the African turquoise killifish (Nothobranchius furzeri) at 3.5, 8.5 and 14 weeks. Total RNA was sequenced and circRNAs were detected.

2019-07-31 | GSE134065 | GEO

Nothobranchius furzeri

Project description:Turquoise killifish (Nothobranchius furzeri) gut microbiota

| PRJNA379271 | ENA

Project description:Single cell RNA-seq of male and female African turquoise killifish tissues

| PRJNA952805 | ENA

Senolytics improve the neurogenic potential of non-glial progenitors and neurorepair in the dorsal pallium of aged killifish independent of inflammation

Project description:With advancing age, senescent cells accumulate as they are not efficiently cleared by the immune system anymore. Via a senescence-associated secretory phenotype, chronic senescent cells alter the microenvironment, creating an unfavorable milieu for neurogenesis and neurorepair. Using an innovative and rapid aging model, the African turquoise killifish, we have previously demonstrated a dramatic decline in neurogenic potential of non-glial progenitors with age. Even after traumatic brain injury, progenitor proliferation and neuron production was very low in aged killifish in comparison to young adult killifish, and overall neurorepair was incomplete. In the present study, we validated if the senolytic cocktail dasatinib and quercetin (D+Q) could reboot the neurogenic output by clearing chronic senescent cells from the aged killifish brain to re-create the necessary supportive environment. Our results confirm that the aged killifish telencephalon holds a very high senescent cell burden, which we could diminish by short-term systemic D+Q treatment. As a consequence of D+Q administration, proliferation of non-glial progenitors increased and more new neurons were generated and migrated into the parenchyma after injury. Injury-induced inflammation and glial scarring, a phenomenon only seen in aged killifish, remained unaltered. Senolytic treatment with D+Q might thus hold promise for improving brain function in aged populations, and is especially interesting for reviving the neurogenic potential of an already aged central nervous system.

2023-07-20 | PXD036437 | Pride

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