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Effect of ZFPM2-AS1 knockdown on gene expression of breast malignant phyllode tumor cells.

ABSTRACT: Effect of ZFPM2-AS1 knockdown on gene expression of breast malignant phyllode tumor cells.

PROVIDER: PRJNA985637 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR24975977_1.fastq.gz	Fastqsanger.gz
	SRR24975977_2.fastq.gz	Fastqsanger.gz
	SRR24975978_1.fastq.gz	Fastqsanger.gz
	SRR24975978_2.fastq.gz	Fastqsanger.gz
	SRR24975979_1.fastq.gz	Fastqsanger.gz

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Effect of ZFPM2-AS1 knockdown on gene expression of breast malignant phyllode tumor cells.

Project description:ZFPM2-AS1 can promote the proliferation, migration and invasion of tumor cells, but its mechanism is still unclear.To investigate the molecular mechanism of malignant progression of breast phyllode tumors, we knocked down the expression of ZFPM2-AS1 in malignant phyllode tumor cells, and detected the genes regulated by ZFPM2-AS1 by RNAseq.

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Project description:In this study, we used miRNA sequencing to analyze and identify possible miRNAs that can be regulated by and ELF3-AS1 in gastric cancer. The results showed that lncRNA ELF3-AS1 knockdown decreased the expression of miR-33a/b and miR-203a. Due to miR-33a/b and miR-203a were able to target SNAI2 expression, and ELF3-AS1 knockdown significantly upregulates SNAI2 expression, we speculated ELF3-AS1 may negatively regulate SNAI2 expression through positively regulating the expression of miR-33a/b and miR-203a in GC.

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