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The Heparin-binding hemagglutinin protein of Mycobacterium tuberculosis is a nucleoid-associated protein

ABSTRACT: The Heparin-binding hemagglutinin protein of Mycobacterium tuberculosis is a nucleoid-associated protein

PROVIDER: PRJNA985662 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR24974571_1.fastq.gz	Fastqsanger.gz
	SRR24974571_2.fastq.gz	Fastqsanger.gz
	SRR24974572_1.fastq.gz	Fastqsanger.gz
	SRR24974572_2.fastq.gz	Fastqsanger.gz
	SRR24974573_1.fastq.gz	Fastqsanger.gz

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Virulence regulator EspR of Mycobacterium tuberculosis is a nucleoid-associated protein

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Project description:mIHF is a possible nucleoid associated protein. Its effect on gene regulation remains unknown. We performed an RNA-seq analysis of the mihF conditional knock-down mutant in Mycobacterium tuberculosis. We show that mihF is essential for in vitro growth and that depeltion of mIHF results in deregulation of a large number of genes. Notably, the most downregulated gene was the espACD operon, which is necessary for secretion of M. tuberculosis main virulence factor EsxA.

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