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SARS-CoV-2 infection triggers pro-atherogenic inflammatory responses in human coronary [plaque]

ABSTRACT: SARS-CoV-2 infection triggers pro-atherogenic inflammatory responses in human coronary [plaque]

PROVIDER: PRJNA986067 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR24981483_1.fastq.gz	Fastqsanger.gz
	SRR24981483_2.fastq.gz	Fastqsanger.gz
	SRR24981484_1.fastq.gz	Fastqsanger.gz
	SRR24981484_2.fastq.gz	Fastqsanger.gz
	SRR24981485_1.fastq.gz	Fastqsanger.gz

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SARS-CoV-2 infection triggers pro-atherogenic inflammatory responses in human coronary

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SARS-CoV-2 infection triggers pro-atherogenic inflammatory responses in human coronary [plaque]

Project description:COVID-19 patients present higher risk for myocardial infarction (MI), acute coronary syndrome, and stroke for up to 1 year after SARS-CoV-2 infection. While the systemic inflammatory response to SARS-CoV-2 infection likely contributes to this increased cardiovascular risk, whether SARS35 CoV-2 directly infects the coronary vasculature and attendant atherosclerotic plaques to locally promote inflammation remains unknown. Here, we report that SARS-CoV-2 viral RNA (vRNA) is detectable and the virus replicates in coronary atherosclerotic lesions taken at autopsy from patients with severe COVID-19.

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