Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

RNA-Seq profiling of circular RNAs in colorectal cancer and circST7L as a potential biomarker

ABSTRACT: RNA-Seq profiling of circular RNAs in colorectal cancer and circST7L as a potential biomarker

PROVIDER: PRJNA987707 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR25030256_1.fastq.gz	Fastqsanger.gz
	SRR25030256_2.fastq.gz	Fastqsanger.gz
	SRR25030257_1.fastq.gz	Fastqsanger.gz
	SRR25030257_2.fastq.gz	Fastqsanger.gz
	SRR25030258_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 20

Similar Datasets

RNA-Seq profiling of circular RNAs in colorectal cancer and circST7L as a potential biomarker

Project description:Aberrant expression of circular RNAs (circRNAs) has been reported in a variety of cancers. CircRNAs may serve as candidate biomarkers and have implications for cancer diagnosis and treatment. RNA-sequencing (RNA-seq) was applied to detect circRNA expression in five CRC and paired normal tissues. Quantitative reverse-transcription polymerase chain reaction (qRT-PCR) was performed to measure circRNA expression, and the receiver operating characteristic curve was used to assess the diagnostic value of circRNA as a biomarker in 50 patients. A total of 1602 circRNAs were differentially expressed, including 743 upregulated and 859 downregulated circRNAs in CRC. CircST7L (hsa_circ_0110464) has a high diagnostic value for CRC. The expression of circST7L was closely associated with tumor size (P=0.024), grade (P=0.017), depth of invasion (P=0.034) and lymph node metastasis (P=0.001). In addition, prediction of circRNA-miRNA interactions identified miR-6821-5p, miR-1908-3p, and miR-6748-5p as pivotal targets of differentially expressed circRNAs. Finally, we predicted 7 miRNAs that may bind to circST7L and 13 target genes for these miRNAs. This study demonstrated that circRNAs were differentially expressed between CRC and normal tissues, and suggested that circST7L might be a promising diagnostic biomarker for CRC.

2023-09-01 | GSE235850 | GEO

Circular RNAs expression profiling in human colorectal cancer

Project description:Circular RNAs expression profiling in human colorectal cancer

| PRJNA615670 | ENA

Potential and functional prediction of six Circular RNAs as diagnostic markers for colorectal cancer

Project description:Potential and functional prediction of six Circular RNAs as diagnostic markers for colorectal cancer

| PRJNA813303 | ENA

RNA-Seq profiling of circular RNAs in human colorectal cancer 5-fluorouracil resistance and the potential biomarkers

Project description:RNA-Seq profiling of circular RNAs in human colorectal cancer 5-fluorouracil resistance and the potential biomarkers

| PRJNA752379 | ENA

Circular DNA tumor viruses make circular RNAs

Project description:Circular DNA tumor viruses make circular RNAs

| PRJNA483204 | ENA

Circular RNAs in nasopharyngeal carcinoma cell lines with different metastasis potential

Project description:Circular RNAs in nasopharyngeal carcinoma cell lines with different metastasis potential

| PRJNA565807 | ENA

Hsa_circ_101555 functions as a competing endogenous RNA of miR-597-5p to promote colorectal cancer progression [Circular RNAs]

Project description:Circular RNAs (circRNAs) represent critical roles in the biology of various cancers. However, their expression patterns and biological functions in human colorectal cancer (CRC) remain largely unknown. The aim of this study was to explore circRNAs profiles in CRC and investigate key circRNAs involved in CRC tumourigenesis and progression.

2019-02-06 | GSE126094 | GEO

RNA-Seq profiling of circular RNAs in human colorectal cancer 5-fluorouracil resistance and the potential biomarkers

Project description:Colorectal cancer（CRC）is a commonly diagnosed cancer of the digestive system worldwide. Although chemotherapeutic agents and targeted therapeutic drugs are currently available for CRC treatment, drug resistance is a problem that cannot be ignored and needs to be solved. 5-Fluorouracil (5-Fu) is a first-line chemotherapeutic agent for colorectal cancer, to explore the role of circular RNA (circRNA) in 5-Fu resistance, we performed the circRNA expression profile in two CRC cell lines and their homologous 5-Fu resistant cells by high-throughput sequencing. We validated the differentially expressed circRNAs in other two paired CRC cells, confirmed that circ_0002813 and circ_0000236 could have a potential ceRNA mechanism and be involved in the formation of 5-Fu resistance. And we combined the sequencing results of mRNA to construct the regulatory network of circRNA-miRNA-mRNA. Our study revealed that circ_0002813 and circ_0000236 may as the biomarkers to predict the occurrence of 5-Fu resistance in CRC.

2024-08-05 | GSE181537 | GEO

Microarray expression profile analysis of circular RNAs in human pancreatic ductal adenocarcinoma

Project description:To explore the potential involvement of circular RNAs (circRNAs) in pancreatic ductal adenocarcinoma (PDAC) oncogenesis, we conducted circRNA profiling in six pairs of human PDAC and adjacent normal tissue by microarray. Our results showed that clusters of circRNAs were aberrantly expressed in PDAC compared with normal samples, and provided potential targets for future treatment of PDAC and novel insights into PDAC biology. Analyze circular RNA expression in pancreatic ductal adenocarcinoma (PDAC) by microarray platform.

2015-11-20 | E-GEOD-69362 | biostudies-arrayexpress

SLC2525-AS1: a potential lncRNA biomarker for radiotherapy sensitivity of colorectal carcinoma

Project description:SLC2525-AS1: a potential lncRNA biomarker for radiotherapy sensitivity of colorectal carcinoma

| PRJNA377842 | ENA