Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Single cell susceptibility to SARS-CoV-2 infection is driven by variable cell states [bulkRNA-Seq]

ABSTRACT: Single cell susceptibility to SARS-CoV-2 infection is driven by variable cell states [bulkRNA-Seq]

PROVIDER: PRJNA993151 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR25223541_1.fastq.gz	Fastqsanger.gz
	SRR25223541_2.fastq.gz	Fastqsanger.gz
	SRR25223542_1.fastq.gz	Fastqsanger.gz
	SRR25223542_2.fastq.gz	Fastqsanger.gz
	SRR25223543_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 30

Similar Datasets

Single cell susceptibility to SARS-CoV-2 infection is driven by variable cell states [bulkRNA-Seq]

Project description:The ability of a virus to infect a cell type is partly determined by host factors required for the viral life cycle. However, not every cell of a given type is equally susceptible, suggesting that our knowledge of the full spectrum of factors that promote infection is incomplete. Profiling the susceptible subsets of cells could reveal additional host factors, but viral infection dramatically alters the state of the cell, obscuring the state of these cells prior to infection. We used single-cell clone tracing to retrospectively identify cells that were highly susceptible to infection with SARS-CoV-2. Our approach revealed candidate factors playing roles in viral entry and regulation of the infectable cell state itself. Patient samples revealed heterogeneous expression of these factors in vivo, with heightened expression in particular inflammatory pathologies. Thus, variable expression of intrinsic cell states is a major determinant of whether individual cells can be infected by SARS-CoV-2.

2023-07-12 | GSE236939 | GEO

Single cell susceptibility to SARS-CoV-2 infection is driven by variable cell states

Project description:Single cell susceptibility to SARS-CoV-2 infection is driven by variable cell states

| PRJNA993158 | ENA

Single cell susceptibility to SARS-CoV-2 infection is driven by variable cell states [scRNA-Seq]

Project description:Single cell susceptibility to SARS-CoV-2 infection is driven by variable cell states [scRNA-Seq]

| PRJNA993165 | ENA

Single cell susceptibility to SARS-CoV-2 infection is driven by variable cell states [scRNA-Seq]

2023-07-12 | GSE236941 | GEO

Single cell susceptibility to SARS-CoV-2 infection is driven by variable cell states

Project description:This SuperSeries is composed of the SubSeries listed below.

2023-07-12 | GSE236942 | GEO

Evolutionarily guided transcription factor design programs novel T cell states [bulkRNA-seq]

Project description:Evolutionarily guided transcription factor design programs novel T cell states [bulkRNA-seq]

| PRJNA1178726 | ENA

Tsc2 coordinates differentiation [bulkRNA-seq]

Project description:Tsc2 coordinates differentiation [bulkRNA-seq]

| PRJNA954865 | ENA

Campylobacter isolates variable, Sweden

Project description:Campylobacter isolates variable, Sweden

| PRJEB40817 | ENA

Single-cell sequencing of glioblastoma reveals central nervous system susceptibility to SARS-CoV-2

Project description:Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused the recent global COVID-19 outbreak, which led to a public health emergency. Entry of SARS-CoV-2 into human cells is dependent on the SARS-CoV receptor, angiotensin converting enzyme 2 (ACE2) receptor, and cathepsin. Cathepsin degrades the spike protein (S protein), which results in the entry of viral nucleic acid into the human host cell. Methods: We explored the susceptibility of the central nervous system (CNS) to SARS-CoV-2 infection using single-cell transcriptome analysis of glioblastoma. Results: The results showed that ACE2 expression is relatively high in endothelial cells (ECs), bone marrow mesenchymal stem cells (BMSCs), and neural precursor cells (NPCs). Cathepsin B (Cat B) and cathepsin (Cat L) were also strongly expressed in various cell clusters within the glioblastoma microenvironment. Immunofluorescence staining of glioma and normal brain tissue chips further confirmed that ACE2 expression co-localized with CD31, CD73, and nestin, which confirmed the susceptibility to SARS-CoV-2 of nervous system cells, including ECs, BMSCs and NPCs, from clinical specimens. Conclusions: These findings reveal the mechanism of SARS-CoV-2 neural invasion and suggest that special attention should be paid to SARS-CoV-2-infected patients with neural symptoms, especially those who suffered a glioma.

2020-11-12 | GSE157424 | GEO

Lymph Node Stromal Cell Responses to Perinatal T Cell Waves, A Temporal Atlas [bulkRNA-Seq]

Project description:Lymph Node Stromal Cell Responses to Perinatal T Cell Waves, A Temporal Atlas [bulkRNA-Seq]

| PRJNA1024482 | ENA