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Exploring the Impact of Cyclodipeptide on Fungal Metabolism: Insights into Membrane and Metabolic Responses [B. cinerea]

ABSTRACT: Exploring the Impact of Cyclodipeptide on Fungal Metabolism: Insights into Membrane and Metabolic Responses [B. cinerea]

PROVIDER: PRJNA994425 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR25255632_1.fastq.gz	Fastqsanger.gz
	SRR25255632_2.fastq.gz	Fastqsanger.gz
	SRR25255633_1.fastq.gz	Fastqsanger.gz
	SRR25255633_2.fastq.gz	Fastqsanger.gz
	SRR25255634_1.fastq.gz	Fastqsanger.gz

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Exploring the Impact of Cyclodipeptide on Fungal Metabolism: Insights into Membrane and Metabolic Responses [B. cinerea]

Project description:This study investigates the effects of cyclodipeptide on fungal and nematode metabolism, specifically focusing on its impact on membrane composition and metabolic responses. Metabolomic profiles of treated and untreated fungal cultures were compared to unravel the molecular changes induced by cyclodipeptide, with a particular emphasis on membrane phospholipids such as monoolein and phosphatidyl ethanolamine, as well as other plasma membrane components like ergosterol and its derivative products. The results reveal significant alterations in the metabolites present in the presence of cyclodipeptide. Specifically, the levels of cyclo (Pro-Tyr) monoolein were found to decrease, while phosphatidyl ethanolamine levels increased. Moreover, the levels of ergosterol and its derivatives were observed to decrease as well. These findings indicate that cyclodipeptide has a profound impact on the metabolic pathways of the fungal system under investigation. The study suggests that cyclodipeptide not only influences membrane phospholipids but may also have broader effects on membrane proteins, cellular signaling, and communication. Furthermore, the observed changes in metabolomic profiles hint at potential alterations in cellular processes beyond membrane composition, possibly involving gene expression and enzyme activity. Understanding the mechanisms behind these effects holds considerable scientific interest and practical implications. The ability of cyclodipeptide to selectively target membrane components presents opportunities for studying and manipulating membrane function in various organisms. Additionally, the discovery of new bioactive natural products like cyclodipeptide opens avenues for developing innovative therapeutics or agricultural agents. Further research is needed to fully comprehend the intricate mechanisms underlying the observed effects of cyclodipeptide on fungal metabolism.

2023-07-23 | GSE237225 | GEO

Exploring the Impact of Cyclodipeptide on Fungal Metabolism: Insights into Membrane and Metabolic Responses

Project description:Exploring the Impact of Cyclodipeptide on Fungal Metabolism: Insights into Membrane and Metabolic Responses

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Exploring the Impact of Cyclodipeptide on Fungal Metabolism: Insights into Membrane and Metabolic Responses [C. elegans]

Project description:Exploring the Impact of Cyclodipeptide on Fungal Metabolism: Insights into Membrane and Metabolic Responses [C. elegans]

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Exploring the Impact of Cyclodipeptide on Fungal Metabolism: Insights into Membrane and Metabolic Responses [C. elegans]

2023-07-23 | GSE237224 | GEO

Exploring the Impact of Cyclodipeptide on Fungal Metabolism: Insights into Membrane and Metabolic Responses

Project description:This SuperSeries is composed of the SubSeries listed below.

2023-07-23 | GSE237226 | GEO

Modifications of fungal membrane proteins profile under pathogenicity induction: a proteomic analysis of Botrytis cinerea membranome.

Project description:Botrytis cinerea is a model phytopathogenic fungus that infects more than 200 different relevant crops, thus being classified among the top ten fungal plant diseases. B. cinerea exhibits a wide arsenal of tools to infect plant tissues. Most of these factors are related to signal transduction cascades, in which membrane proteins play a key role as a bridge between environmental conditions and intracellular molecular processes. This work describes the first proteomic approach to study the membranome of B. cinerea under different pathogenicity condition induced by using different plant-based elicitors: Glucose and Tomato Cell Wall (TCW). A discovery proteomics analysis of membrane protein extracts was carried out by mass spectrometry. A total of 2,794 proteins were successfully identified, and approximately 46% of them could be classified as membrane proteins based on the presence of transmembrane regions and covalent post-translational modifications. Further analyses showed significant differences in the fungal membranome composition depending on the available carbon source: 804 proteins were exclusively identified when the fungus was cultured in the presence of glucose as sole carbon source, and 251 proteins were exclusively identified in the presence of TCW. Besides, among the 1737 common proteins, a subset of 898 proteins presented clear differences in their abundance and in order to clarify the specific changes produced in the membranome, proteins were categorized according to their gene ontology annotation shown different profiles. As a result of this work, we present here the first description of the membranome of B. cinerea, which will certainly provide a better understanding of this important subproteome in B. cinerea.

2016-07-11 | PXD003099 | Pride

PPH24 - Botrytis cinerea Steroidal glycoalkaloids

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The VELVET complex in the gray mold fungus Botrytis cinerea: impact of BcLAE1 on differentiation, secondary metabolism and virulence

Project description:Full transcriptomes of the Botrytis cinerea wild-type strain B0510 and the null-mutants deltaBcVEL1 and deltaBcLAE1, cultured onto solid grape juice medium with cellophane overlays , were compared to identify BcVEL1 or/and BcLAE1-dependent genes. The Botrytis cinerea wild-type strain and the null-mutants deltaBcVEL1 and BcLAE1 were cultured for 48h onto solid grape juice medium with cellophane overlays. 4 replicates were performed. The 12 total-RNA samples (3 strains* 4 replicates) were used for hybridization on NimbleGen 4plex gene expression arrays (20,885 gene models from Botrytis cinerea with three 60-mer probes per gene).

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