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The pathological alterations in hearts from polycystic ovary syndrome mice [NWZ_HFD]

ABSTRACT: The pathological alterations in hearts from polycystic ovary syndrome mice [NWZ_HFD]

PROVIDER: PRJNA997919 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR25396573_1.fastq.gz	Fastqsanger.gz
	SRR25396573_2.fastq.gz	Fastqsanger.gz
	SRR25396574_1.fastq.gz	Fastqsanger.gz
	SRR25396574_2.fastq.gz	Fastqsanger.gz
	SRR25396575_1.fastq.gz	Fastqsanger.gz

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The pathological alterations in hearts from polycystic ovary syndrome mice

Project description:The pathological alterations in hearts from polycystic ovary syndrome mice

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The pathological alterations in hearts from polycystic ovary syndrome mice [female_PAMH]

Project description:The pathological alterations in hearts from polycystic ovary syndrome mice [female_PAMH]

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The pathological alterations in hearts from polycystic ovary syndrome mice [male_PAMH]

Project description:The pathological alterations in hearts from polycystic ovary syndrome mice [male_PAMH]

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The pathological alterations in hearts from polycystic ovary syndrome mice [male_PAMH]

Project description:Polycystic ovary syndrome (PCOS), the most common endocrine disease in reproductive-aged women, is associated with an increased prevalence and extent of coronary artery disease. However, the underlying mechanism remains unclear. Here, we observed that hearts from PCOS mice were characterized by increased total macrophage accumulation. Monocyte-derived macrophages were significantly increased in the hearts of PCOS mice owing to enhanced circulating monocyte supply. Compared with control mice, PCOS mice showed a significant increase in splenic monocyte output, associated with elevated hematopoietic progenitors in the spleen and sympathetic tone. Compared with non-PCOS animals, PCOS-induced mice showed significantly exacerbated atherosclerotic plaque development and post-MI cardiac remodeling. Conditional Vcam1 silencing in PCOS mice significantly suppressed cardiac inflammation and improved post-MI cardiac injury. Our data documented new mechanisms through which PCOS may affect cardiovascular health in women.

2024-01-02 | GSE238074 | GEO

The pathological alterations in hearts from polycystic ovary syndrome mice [NWZ_HFD]

2024-01-02 | GSE238073 | GEO

The pathological alterations in hearts from polycystic ovary syndrome mice [female_PAMH]

2024-01-02 | GSE238072 | GEO

The pathological alterations in hearts from polycystic ovary syndrome mice

Project description:This SuperSeries is composed of the SubSeries listed below.

2024-01-02 | GSE238075 | GEO

Identification of microRNAs involved in polycystic ovary syndrome based on High-throughput sequencing [miRNA-seq]

Project description:Aberration in miRNA expression or DNA methylation is a causal factor for numerous pathological conditions including polycystic ovarian syndrome PCOS, a common endocrine disorders and leading cause of infertility. The epigenetic interactions between miRNA and DNA methylation remain unexplored in PCOS. Few studies have reported that the regulation of miRNAs in polycystic ovary syndrome(PCOS). Our study helps to understand the molecular pathogenesis of PCOS in human ovarian granulosa cells from the perspective of post-transcriptional level.

2019-10-09 | GSE138572 | GEO

GWAS of Polycystic Ovary Syndrome Phenotypes

Project description:GWAS of Polycystic Ovary Syndrome Phenotypes

| PRJNA75733 | ENA

Transcriptome Profiling Reveals the key genes and pathways involved in polycystic ovary syndrome [RNA-seq]

Project description:Aberration in miRNA expression or DNA methylation is a causal factor for numerous pathological conditions including polycystic ovarian syndrome PCOS, a common endocrine disorders and leading cause of infertility. The epigenetic interactions between miRNA and DNA methylation remain unexplored in PCOS. Few studies have reported that the key genes and pathways involved in polycystic ovary syndrome(PCOS). Our study helps to understand the molecular pathogenesis of PCOS in human ovarian granulosa cells and identifiy genes and pathways that may be potential therapeutic targets for PCOS treatment..

2019-10-08 | GSE138518 | GEO

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