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Gene expression signature in ablated IL-38 PyMT tumors dependent on 훾훿 T cells

ABSTRACT: Gene expression signature in ablated IL-38 PyMT tumors dependent on 훾훿 T cells

PROVIDER: PRJNA999220 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR25436837.fastq.gz	Fastqsanger.gz
	SRR25436838.fastq.gz	Fastqsanger.gz
	SRR25436839.fastq.gz	Fastqsanger.gz
	SRR25436840.fastq.gz	Fastqsanger.gz
	SRR25436841.fastq.gz	Fastqsanger.gz

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Gene expression signature in ablated IL-38 PyMT tumors dependent on T cells

Project description:We studied the impact of IL-38 neutralization on tumor immune control in PyMT mammary carcinoma mouse model via γδ T cells. To that end, whole transcriptome profile of PyMT tumors upon in vivo IL-38 neutralization and γδ-TCR blockage were generate via next generation mRNA sequencing on a NextSeq 2000 sequencer.

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Top-down analysis of purified IL-38

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Expression data from MMTV-PyMT Induced Tumors

Project description:Loss of E2F transcription factos alters metastatic capacity of MMTV-PyMT tumors. We used microarrays to futher characterize the effects of E2F loss on mammary tumorigenesis in MMTV-PyMT mice.

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Gene expression profiles of the mammary gland tumors from Nr1d1+/+;PyMT and Nr1d1-/-;PyMT mice

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Project description:To investigate effect of IFNg in the plasticity of PyMT, we treated PyMT with IFNg for 24h then FACS sorted the CD90pos and CD90neg PyMT. We then performed gene expression profiling analysis using data obtained from RNA-seq of 2 different PyMT cells

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Differential Gene expression in the mouse mammary tumors of PyMT-Malat1 wild-type (WT), PyMT-Malat1 knockout (KO) and PyMT-Malat1 knockout with Malat1 transgene expression (TG)

Project description:Previously, lncRNA Malat1 knockout mice were generated by insertional inactivation. By crossing this line to MMTV-PyMT mammary tumor mouse model, we produced PyMT;Malat1 wild-type (WT) and PyMT;Malat1 knockout (KO). Furthermore, we generated Malat1 transgenic mice by targeting ROSA26 locus and bred them to PyMT;Malat1 knockout mice to produce Malat1-rescued PyMT;Malat1 knockout;Malat1 transgenic animals (TG). Using mammary tumors from the three groups of animals, we performed RNA-Seq analysis to identify differentially up-regulated genes in KO tumors to find novel target genes of YAP-TEAD pathway.

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Transcription profiling of mouse AKR/J x PyMT F1 versus DBA/2J x PyMT F1 tumors

Project description:F1 hybrids from (AKR/J x FVB/NJ) and (DBA/2J x FVB/NJ) outcrosses display a 20-fold difference in mammary tumor metastatic capacity, due to differences in inherited polymorphisms. Expression studies were performed to determine whether polymorphism-driven gene expression signatures predictive of outcome could be generated from mouse tumor tissues Experiment Overall Design: Mammary tumors from adult F1 animals from (AKR/J x PyMT) and (DBA/2J x PyMT) outcrosses was collected and arrayed on Affymetrics chip to identify basal differences in gene expression between the different genotypes

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