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ProteomicsDistinct lactation-associated macrophages exist in murine mammary tissue and human milk
Macrophages are involved in immune defense, organogenesis and tissue homeostasis. They also contribute to the different phases of mammary gland remodeling during development, pregnancy and involution post-lactation. Yet, less is known about the dynamics of mammary gland macrophages in the lactation s...
ORGANISM(S): Mus Musculus (mouse) 
2023-06-23 | PXD041711 | Pride
Lactation Mammary gland Macrophages Milk 
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UnknownTissue microenvironment dictates the fate and tumor-suppressive function of type 3 ILCs.
Not available
S-EPMC5551572 | biostudies-literature
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ProteomicsV. longisporum elicits media-dependent secretome responses with a further capacity to distinguish between plant-related environments
Plant pathogens secrete distinct effector molecules in their host plants to establish successful infections. Verticillium longisporum colonizes the vascular system of the plant. We analyzed the exoproteome of the fungus dependent on different environmental conditions including non plant-related and p...
ORGANISM(S): Verticillium Longisporum 
2020-07-27 | PXD018533 | Pride
Verticillium longisporum Plant pathogen Exoproteome Brassica napus Secretome Xylem sap 
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UnknownNew insights into IL-12-mediated tumor suppression.
Not available
S-EPMC4291488 | biostudies-literature
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ProteomicsPD-1-targeted immunotherapy in NASH-triggered liver cancer induces pro-tumorigenic environment through CD8+PD-1+ T-cells
Immunotherapy has opened hitherto unknown possibilities to treat cancer. Whereas some cancer types (e.g. melanoma) can be efficiently treated, others lack measurable positive effects (e.g. PDAC). Moreover, stratification of responders/non-responders is only possible in some cancer types (e.g. melanom...
ORGANISM(S): Mus Musculus (mouse) 
2021-03-03 | PXD017236 | Pride
Immunotherapy Nash Cd8+pd1+ 
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TranscriptomicsC-Myb+ erythro-myeloid progenitor-derived fetal monocytes give rise to adult tissue-resident macrophages
...etic cells, tissue-resident macrophages are selfrenewing and maintained independently of adult hematopoiesis. While most macrophages originate from embryonic precursors that seed tissues prior to birth, their exact origin is unknown. Using an in utero macrophage depletion strategy and fatemapping of ...
ORGANISM(S): Mus musculus 
2015-04-23 | E-GEOD-66970 | biostudies-arrayexpress
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TranscriptomicsRNA-seq of small intestinal macrophages, neutrophils, CD103-CD11b+cDC and cryptopatch and ILF associated mononuclear phagocytes (CIA-MPh)
Cryptopatches (CP) and isolated lymphoid follicles (ILF) are evolutionary ancient lymphoid structures found in the intestines of all vertebrates. These structures are demarcated by a poorly characterised subset of mononuclear phagocytes (MPh), called CP/ILF-associated (CIA)-MPh. CIA-MPh expressed ve...
ORGANISM(S): Mus musculus 
2020-11-24 | E-MTAB-9505 | biostudies-arrayexpress
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TranscriptomicsSingle cell RNA-sequencing of epithelial cells, endothelial cells and macrophages from mouse submandibular salivary glands
The salivary glands often become damaged in individuals receiving radiotherapy for head and neck cancer, resulting in chronic dry mouth. This leads to detrimental effects on their health and quality of life, for which there is no regenerative therapy. Macrophages are the predominant immune cell in th...
ORGANISM(S): Mus musculus 
2023-10-01 | E-MTAB-13374 | biostudies-arrayexpress
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TranscriptomicsSingle cell RNA sequencing of small intestinal dendritic cells from C57BL/6, RORgt-/- and RORgt-Cre x Ltb-flox mice
Cryptopatches (CP) and isolated lymphoid follicles (ILF) are evolutionary ancient lymphoid structures found in the intestines of all vertebrates. These structures are demarcated by a poorly characterised subset of mononuclear phagocytes (MPh), called CP/ILF-associated (CIA)-MPh. We could demonstrate...
ORGANISM(S): Mus musculus 
2020-11-24 | E-MTAB-9522 | biostudies-arrayexpress
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