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ProteomicsProtein profile of follicular fluid from the heat-stressed cow
Direct exposure to physiologically-relevant elevated temperatures during the first half of in vitro maturation heightens cumulus-derived progesterone production, suppresses matrix metallopeptidase 9 secretion, and alters cumulus transcriptome. We hypothesized that heat-induced perturbations in cumulu...
ORGANISM(S): Bos Taurus (bovine) 
2020-01-13 | PXD015735 | Pride
Bovine Lc-msms Tmt Heat stress Follicular fluid 
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Proteomics,MultiomicsAsparaginase and GSK3A inhibitor treatment of CCRF-CEM cells
Resistance to asparaginase, an antileukemic enzyme that depletes asparagine, is a common clinical problem. Using a genome-wide CRISPR/Cas9 screen, we found a synthetic lethal interaction between Wnt pathway activation and asparaginase in acute leukemias resistant to this enzyme. Wnt pathway activati...
ORGANISM(S): Homo Sapiens (human) 
2019-03-29 | PXD013061 | Pride
Gsk3 Leukemia Asparaginase 
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ProteomicsShotgun proteome analysis of Hemerocallis citrina floral and extrafloral nectar
Many angiosperms can secret at least two types of sugar-rich liquids, floral nectar (FN) and extrafloral nectar (EFN), by which plants can make use of the animal partner’s mobility for pollen transportation and attract predatory animals for indirect defense. Both FN and EFN contain considerable amount...
ORGANISM(S): Hemerocallis Citrina 
2023-03-11 | PXD025892 | Pride
Extrafloral nectar Hemerocallis citrina Floral Nectarin 
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UnknownRandomized Phase III Trial Comparing ABVD Plus Radiotherapy With the Stanford V Regimen in Patients With Stages I or II Locally Extensive, Bulky Mediastinal Hodgkin Lymphoma: A Subset Analysis of the North American Intergroup E2496 Trial.
Not available
S-EPMC4451176 | biostudies-literature
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UnknownPhase III randomized intergroup trial of CHOP plus rituximab compared with CHOP chemotherapy plus (131)iodine-tositumomab for previously untreated follicular non-Hodgkin lymphoma: SWOG S0016.
Not available
S-EPMC3732010 | biostudies-literature
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ProteomicsIL1B Fibrosis Secretome Samples
Our results identify IL-1β induced immune-competency in human cardiac fibroblasts and suggest that fibroblast secretome modulation may constitute a therapeutic approach to PAH and other diseases typified by inflammation and fibrotic remodeling.
ORGANISM(S): Homo Sapiens (human) 
2024-01-26 | PXD044147 | Pride
Il1b Fibrosis 
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UnknownPhase II Intergroup Trial of Alisertib in Relapsed and Refractory Peripheral T-Cell Lymphoma and Transformed Mycosis Fungoides: SWOG 1108.
Not available
S-EPMC4500834 | biostudies-literature
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UnknownRandomized phase III trial of ABVD versus Stanford V with or without radiation therapy in locally extensive and advanced-stage Hodgkin lymphoma: an intergroup study coordinated by the Eastern Cooperative Oncology Group (E2496).
Not available
S-EPMC3574266 | biostudies-literature
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UnknownContinued Excellent Outcomes in Previously Untreated Patients With Follicular Lymphoma After Treatment With CHOP Plus Rituximab or CHOP Plus 131I-Tositumomab: Long-Term Follow-Up of Phase III Randomized Study SWOG-S0016.
Not available
S-EPMC6553811 | biostudies-literature
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ProteomicsProteomic analysis of whole brains from Ndufs4-/- mice treated with doxycycline
Mice with mitochondrial complex I deficiency (Ndufs4-/-) suffer from severe energy impairment primarily affecting the brain and die at P55. A small molecule screen developed by our lab using cells harboring human mitochondrial disease mutations identified antibiotics targeting mitochondrial translatio...
ORGANISM(S): Mus Musculus (mouse) 
2021-09-09 | PXD022860 | Pride
Mouse brain Mitochondrial disease Mitochondrial translation Tetracycline 
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